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dc.contributor.authorWells, Christineen_US
dc.contributor.authorSalvage-Jones, Judithen_US
dc.contributor.authorBeckhouse, Anthonyen_US
dc.contributor.authorHitchens, Kellyen_US
dc.contributor.authorAshman, Roberten_US
dc.contributor.authorMa, Boen_US
dc.contributor.authorStewart, Laurenen_US
dc.contributor.authorLebus, Danielen_US
dc.contributor.authorSobieszczuk, Peteren_US
dc.description.abstractThe recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus Mincle contributes a novel and non-redundant role in the induction of inflammatory signalling in response to C. albicans infection.en_US
dc.publisherSociety for Glycobiologyen_US
dc.publisher.placeNashville, TN, USAen_US
dc.relation.ispartofconferencenameAnnual Conference of the Society for Glycobiologyen_US
dc.relation.ispartofconferencetitleProgram and Abstracts for the 2007 Meeting of the Society for Glycobiologyen_US
dc.relation.ispartoflocationBoston, MA, USAen_US
dc.titleThe Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicansen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conference Publications (Extract Paper)en_US
dc.type.codeE - Conference Publicationsen_US
gro.hasfulltextNo Full Text

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    Contains papers delivered by Griffith authors at national and international conferences.

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