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dc.contributor.authorWells, Christine A
dc.contributor.authorSalvage-Jones, Judith A
dc.contributor.authorLi, Xin
dc.contributor.authorHitchens, Kelly
dc.contributor.authorButcher, Suzanne
dc.contributor.authorMurray, Rachael Z
dc.contributor.authorBeckhouse, Anthony G
dc.contributor.authorLo, Yu-Lan-Sandra
dc.contributor.authorManzanero, Silvia
dc.contributor.authorCobbold, Christian
dc.contributor.authorSchroder, Kate
dc.contributor.authorMa, Bo
dc.contributor.authorOrr, Sally
dc.contributor.authorStewart, Lauren
dc.contributor.authorLebus, Daniel
dc.contributor.authorSobieszczuk, Peter
dc.contributor.authorHume, David A
dc.contributor.authorStow, Jennifer
dc.contributor.authorBlanchard, Helen
dc.contributor.authorAshman, Robert B
dc.date.accessioned2017-05-03T16:57:46Z
dc.date.available2017-05-03T16:57:46Z
dc.date.issued2008
dc.date.modified2010-01-11T07:55:09Z
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/10072/28193
dc.description.abstractThe recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus Mincle contributes a novel and non-redundant role in the induction of inflammatory signalling in response to C. albicans infection.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSociety for Glycobiology
dc.publisher.placeNashville, TN, USA
dc.publisher.urihttp://www.glycobiology.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameAnnual Conference of the Society for Glycobiology
dc.relation.ispartofconferencetitleJOURNAL OF IMMUNOLOGY
dc.relation.ispartofdatefrom2007-11-11
dc.relation.ispartofdateto2007-11-14
dc.relation.ispartoflocationUnited States
dc.relation.ispartofpagefrom7404
dc.relation.ispartofpagefrom10 pages
dc.relation.ispartofpageto7413
dc.relation.ispartofpageto10 pages
dc.relation.ispartofissue11
dc.relation.ispartofvolume180
dc.rights.retentionY
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode1107
dc.titleThe Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorSalvage-Jones, Judith A.
gro.griffith.authorHitchens, Kelly J.
gro.griffith.authorWells, Christine
gro.griffith.authorBeckhouse, Anthony G.
gro.griffith.authorBlanchard, Helen
gro.griffith.authorCobbold, Christian J.


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    Contains papers delivered by Griffith authors at national and international conferences.

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