dc.contributor.author | Wells, Christine A | |
dc.contributor.author | Salvage-Jones, Judith A | |
dc.contributor.author | Li, Xin | |
dc.contributor.author | Hitchens, Kelly | |
dc.contributor.author | Butcher, Suzanne | |
dc.contributor.author | Murray, Rachael Z | |
dc.contributor.author | Beckhouse, Anthony G | |
dc.contributor.author | Lo, Yu-Lan-Sandra | |
dc.contributor.author | Manzanero, Silvia | |
dc.contributor.author | Cobbold, Christian | |
dc.contributor.author | Schroder, Kate | |
dc.contributor.author | Ma, Bo | |
dc.contributor.author | Orr, Sally | |
dc.contributor.author | Stewart, Lauren | |
dc.contributor.author | Lebus, Daniel | |
dc.contributor.author | Sobieszczuk, Peter | |
dc.contributor.author | Hume, David A | |
dc.contributor.author | Stow, Jennifer | |
dc.contributor.author | Blanchard, Helen | |
dc.contributor.author | Ashman, Robert B | |
dc.date.accessioned | 2017-05-03T16:57:46Z | |
dc.date.available | 2017-05-03T16:57:46Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2010-01-11T07:55:09Z | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.uri | http://hdl.handle.net/10072/28193 | |
dc.description.abstract | The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus Mincle contributes a novel and non-redundant role in the induction of inflammatory signalling in response to C. albicans infection. | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Society for Glycobiology | |
dc.publisher.place | Nashville, TN, USA | |
dc.publisher.uri | http://www.glycobiology.org/ | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofconferencename | Annual Conference of the Society for Glycobiology | |
dc.relation.ispartofconferencetitle | JOURNAL OF IMMUNOLOGY | |
dc.relation.ispartofdatefrom | 2007-11-11 | |
dc.relation.ispartofdateto | 2007-11-14 | |
dc.relation.ispartoflocation | United States | |
dc.relation.ispartofpagefrom | 7404 | |
dc.relation.ispartofpagefrom | 10 pages | |
dc.relation.ispartofpageto | 7413 | |
dc.relation.ispartofpageto | 10 pages | |
dc.relation.ispartofissue | 11 | |
dc.relation.ispartofvolume | 180 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 3204 | |
dc.title | The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dc.type.code | E - Conference Publications | |
gro.date.issued | 2007 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Cobbold, Christian J. | |