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dc.contributor.authorLeonard, J.en_US
dc.contributor.authorCook, A.en_US
dc.contributor.authorVan Gele, M.en_US
dc.contributor.authorSpeleman, F.en_US
dc.contributor.authorSturm, R.en_US
dc.contributor.editorK.I. Baumann, Z. Halata, I. Mollen_US
dc.date.accessioned2017-04-24T14:54:11Z
dc.date.available2017-04-24T14:54:11Z
dc.date.issued2003en_US
dc.date.modified2010-01-11T07:55:21Z
dc.identifier.isbn3540003746en_US
dc.identifier.urihttp://hdl.handle.net/10072/28196
dc.description.abstractWe have examined a number of developmentally regulated transcription factors for expression in Merkel cells and MCC cell lines and demonstrated that their expression patterns may be prognostic in MCC. We have shown that human Merkel cells from adult scalp hair follicle and from neonatal foreskin epidermal sheets express Brn-3c and HATH1. In addition, results demonstrate that the novel Merkel binding activity complex MNF contains Brn-3c. Moreover, Classic lines which retain neuroendocrine phenotype, are slow growing in culture, grow in suspension and are thought to be less aggressive, retain Brn-2, Brn-3c and HATH1 expression, whereas Variant suspension lines which no longer express NE markers retain Brn-2 and Brn-3c expression, but lack HATH1. Further, Type IV Variant lines which grow as adherent monolayers have shorter doubling times, are more radiation- resistant and have higher cloning efficiencies in soft agar, all thought to be indicative of aggressive tumours, have reduced or no Brn-2 proteins and lack expression of Brn-3c and HATH1 transcription factors.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeLondonen_US
dc.publisher.urihttp://books.google.com.au/en_AU
dc.relation.ispartofbooktitleThe Merkel Cell Structure-Development-Function-Cancerogenesisen_US
dc.relation.ispartofchapter30en_US
dc.relation.ispartofpagefrom203en_US
dc.relation.ispartofpageto218en_US
dc.subject.fieldofresearchCell Development, Proliferation and Deathen_US
dc.subject.fieldofresearchcode060103en_US
dc.titleExpression of developmentally regulated transcription factors in Merkel cell carcinomaen_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.date.issued2003
gro.hasfulltextNo Full Text


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