• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain

    Thumbnail
    View/Open
    56051_1.pdf (544.2Kb)
    Author(s)
    Etheridge, Naomi
    Lewohl, Joanne M
    Mayfield, R Dayne
    Harris, R Adron
    Dodd, Peter R
    Griffith University Author(s)
    Lewohl, Joanne M.
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes that alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post‐mortem human brain of six chronic alcoholics and six non‐alcoholic controls were compared using 2‐D differential in‐gel electrophoresis (DIGE). Functionally affected and spared regions (superior frontal gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the ...
    View more >
    Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes that alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post‐mortem human brain of six chronic alcoholics and six non‐alcoholic controls were compared using 2‐D differential in‐gel electrophoresis (DIGE). Functionally affected and spared regions (superior frontal gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty‐nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the OC with an overlap of 23 proteins. Additionally, the SFG was compared to the OC within each group (alcoholics or controls) to identify region‐specific differences. A selection was identified by MALDI‐TOF mass spectrometry revealing proteins involved in vesicle transport, metabolism, folding and trafficking, and signal transduction, all of which have the potential to influence synaptic activity. A number of proteins identified in this study have been previously related to alcoholism; however, the focus on synaptic proteins has also uncovered novel alcoholism‐affected proteins. Further exploration of these proteins will illuminate the mechanisms altering synaptic plasticity, and thus neuronal signaling and response, in the alcoholic brain.
    View less >
    Journal Title
    Proteomics: Clinical Applications
    Volume
    3
    Issue
    6
    DOI
    https://doi.org/10.1002/prca.200800202
    Copyright Statement
    © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article: Proteomics- Clinical Applications, Volume 3 Issue 6, Pages 730 - 742, which has been published in final form at http://dx.doi.org/10.1002/prca.200800202
    Subject
    Proteomics and intermolecular interactions (excl. medical proteomics)
    Medical biochemistry and metabolomics
    Central nervous system
    Publication URI
    http://hdl.handle.net/10072/28478
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander