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  • Sheep and rabbit genital tracts and abdominal walls as an implantation model for the study of surgical mesh

    Author(s)
    Krause, Hannah
    Goh, Judith
    Griffith University Author(s)
    Goh, Judith T.
    Krause, Hannah
    Year published
    2009
    Metadata
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    Abstract
    Aim: In order to evaluate the biocompatible and biomechanical properties of surgical mesh, suitable animal models are required. This paper assesses the sheep and rabbit genital tracts as potential models for direct vaginal implantation of mesh for use in pelvic floor surgery. Methods: Sheep and rabbits were implanted with surgical mesh in the abdominal wall and genital tract. After 12 weeks, the implantation sites were assessed and the mesh was explanted for histological review. Results: Technical aspects of vaginal surgery on the sheep and rabbits are described. Implantation of mesh was achievable in both the sheep ...
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    Aim: In order to evaluate the biocompatible and biomechanical properties of surgical mesh, suitable animal models are required. This paper assesses the sheep and rabbit genital tracts as potential models for direct vaginal implantation of mesh for use in pelvic floor surgery. Methods: Sheep and rabbits were implanted with surgical mesh in the abdominal wall and genital tract. After 12 weeks, the implantation sites were assessed and the mesh was explanted for histological review. Results: Technical aspects of vaginal surgery on the sheep and rabbits are described. Implantation of mesh was achievable in both the sheep and rabbit genital tracts. Following 12 weeks of mesh implantation, there was a high rate of mesh erosion through both the sheep and rabbit vaginal epithelium. Conclusions: Vaginal mesh erosion was present in both the sheep and rabbit genital tract model. The properties of sheep and rabbit vaginal epithelium require further evaluation to determine their comparability to human vaginal epithelium.
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    Journal Title
    Journal of Obstetrics and Gynaecology Research
    Volume
    35
    Issue
    2
    Publisher URI
    http://ttp://www.wiley.com/bw/journal.asp?ref=1341-8076&site=1
    DOI
    https://doi.org/10.1111/j.1447-0756.2008.00930.x
    Subject
    Medical and Health Sciences not elsewhere classified
    Paediatrics and Reproductive Medicine
    Publication URI
    http://hdl.handle.net/10072/28566
    Collection
    • Journal articles

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