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dc.contributor.authorSuzuki, Harukazu
dc.contributor.authorForrest, Alistair RR
dc.contributor.authorvan Nimwegen, Erik
dc.contributor.authorDaub, Carsten O
dc.contributor.authorBalwierz, Piotr J
dc.contributor.authorIrvine, Katharine M
dc.contributor.authorLassmann, Timo
dc.contributor.authorRavasi, Timothy
dc.contributor.authorHasegawa, Yuki
dc.contributor.authorde Hoon, Michiel JL
dc.contributor.authorKatayama, Shintaro
dc.contributor.authorSchroder, Kate
dc.contributor.authorCarninci, Piero
dc.contributor.authorTomaru, Yasuhiro
dc.contributor.authorKanamori-Katayama, Mutsumi
dc.contributor.authorKubosaki, Atsutaka
dc.contributor.authorAkalin, Altuna
dc.contributor.authorAndo, Yoshinari
dc.contributor.authorArner, Erik
dc.contributor.authorAsada, Maki
dc.contributor.authorAsahara, Hiroshi
dc.contributor.authorBailey, Timothy
dc.contributor.authorBajic, Vladimir B
dc.contributor.authorBauer, Denis
dc.contributor.authorBeckhouse, Anthony G
dc.contributor.authorBertin, Nicolas
dc.contributor.authorBjorkegren, Johan
dc.contributor.authorBrombacher, Frank
dc.contributor.authorBulger, Erika
dc.contributor.authorChalk, Alistair M
dc.contributor.authorChiba, Joe
dc.contributor.authorCloonan, Nicole
dc.contributor.authorDawe, Adam
dc.contributor.authorDostie, Josee
dc.contributor.authorEngstrom, Par G
dc.contributor.authorEssack, Magbubah
dc.contributor.authorFaulkner, Geoffrey J
dc.contributor.authorFink, J Lynn
dc.contributor.authorFredman, David
dc.contributor.authorFujimori, Ko
dc.contributor.authorFuruno, Masaaki
dc.contributor.authorGojobori, Takashi
dc.contributor.authorGough, Julian
dc.contributor.authorGrimmond, Sean M
dc.contributor.authorGustafsson, Mika
dc.contributor.authorHashimoto, Megumi
dc.contributor.authorHashimoto, Takehiro
dc.contributor.authorHatakeyama, Mariko
dc.contributor.authorHeinzel, Susanne
dc.contributor.authorHide, Winston
dc.contributor.authorHofmann, Oliver
dc.contributor.authorHornquist, Michael
dc.contributor.authorHuminiecki, Lukasz
dc.contributor.authorIkeo, Kazuho
dc.contributor.authorImamoto, Naoko
dc.contributor.authorInoue, Satoshi
dc.contributor.authorInoue, Yusuke
dc.contributor.authorIshihara, Ryoko
dc.contributor.authorIwayanagi, Takao
dc.contributor.authorJacobsen, Anders
dc.contributor.authorKaur, Mandeep
dc.contributor.authorKawaji, Hideya
dc.contributor.authorKerr, Markus C
dc.contributor.authorKimura, Ryuichiro
dc.contributor.authorKimura, Syuhei
dc.contributor.authorKimura, Yasumasa
dc.contributor.authorKitano, Hiroaki
dc.contributor.authorKoga, Hisashi
dc.contributor.authorKojima, Toshio
dc.contributor.authorKondo, Shinji
dc.contributor.authorKonno, Takeshi
dc.contributor.authorKrogh, Anders
dc.contributor.authorKruger, Adele
dc.contributor.authorKumar, Ajit
dc.contributor.authorLenhard, Boris
dc.contributor.authorLennartsson, Andreas
dc.contributor.authorLindow, Morten
dc.contributor.authorLizio, Marina
dc.contributor.authorMacPherson, Cameron
dc.contributor.authorMaeda, Norihiro
dc.contributor.authorMaher, Christopher A
dc.contributor.authorMaqungo, Monique
dc.contributor.authorMar, Jessica
dc.contributor.authorMatigian, Nicholas A
dc.contributor.authorMatsuda, Hideo
dc.contributor.authorMattick, John S
dc.contributor.authorMeier, Stuart
dc.contributor.authorMiyamoto, Sei
dc.contributor.authorMiyamoto-Sato, Etsuko
dc.contributor.authorNakabayashi, Kazuhiko
dc.contributor.authorNakachi, Yutaka
dc.contributor.authorNakano, Mika
dc.contributor.authorNygaard, Sanne
dc.contributor.authorOkayama, Toshitsugu
dc.contributor.authorOkazaki, Yasushi
dc.contributor.authorOkuda-Yabukami, Haruka
dc.contributor.authorOrlando, Valerio
dc.contributor.authorOtomo, Jun
dc.contributor.authorPachkov, Mikhail
dc.contributor.authorPetrovsky, Nikolai
dc.contributor.authorPlessy, Charles
dc.contributor.authorQuackenbush, John
dc.contributor.authorRadovanovic, Aleksandar
dc.contributor.authorRehli, Michael
dc.contributor.authorSaito, Rintaro
dc.contributor.authorSandelin, Albin
dc.contributor.authorSchmeier, Sebastian
dc.contributor.authorSchonbach, Christian
dc.contributor.authorSchwartz, Ariel S
dc.contributor.authorSemple, Colin A
dc.contributor.authorSera, Miho
dc.contributor.authorSeverin, Jessica
dc.contributor.authorShirahige, Katsuhiko
dc.contributor.authorSimons, Cas
dc.contributor.authorLaurent, George St
dc.contributor.authorSuzuki, Masanori
dc.contributor.authorSuzuki, Takahiro
dc.contributor.authorSweet, Matthew J
dc.contributor.authorTaft, Ryan J
dc.contributor.authorTakeda, Shizu
dc.contributor.authorTakenaka, Yoichi
dc.contributor.authorTan, Kai
dc.contributor.authorTaylor, Martin S
dc.contributor.authorTeasdale, Rohan D
dc.contributor.authorTegner, Jesper
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorValen, Eivind
dc.contributor.authorWahlestedt, Claes
dc.contributor.authorWaki, Kazunori
dc.contributor.authorWaterhouse, Andrew
dc.contributor.authorAWells, Christine
dc.contributor.authorWinther, Ole
dc.contributor.authorWu, Linda
dc.contributor.authorYamaguchi, Kazumi
dc.contributor.authorYanagawa, Hiroshi
dc.contributor.authorYasuda, Jun
dc.contributor.authorZavolan, Mihaela
dc.contributor.authorHume, David A
dc.contributor.authorArakawa, Takahiro
dc.contributor.authorFukuda, Shiro
dc.contributor.authorImamura, Kengo
dc.contributor.authorKai, Chikatoshi
dc.contributor.authorKaiho, Ai
dc.contributor.authorKawashima, Tsugumi
dc.contributor.authorKawazu, Chika
dc.contributor.authorKitazume, Yayoi
dc.contributor.authorKojima, Miki
dc.contributor.authorMiura, Hisashi
dc.contributor.authorMurakami, Kayoko
dc.contributor.authorMurata, Mitsuyoshi
dc.contributor.authorNinomiya, Noriko
dc.contributor.authorNishiyori, Hiromi
dc.contributor.authorNoma, Shohei
dc.contributor.authorOgawa, Chihiro
dc.contributor.authorSano, Takuma
dc.contributor.authorSimon, Christophe
dc.contributor.authorTagami, Michihira
dc.contributor.authorTakahashi, Yukari
dc.contributor.authorKawai, Jun
dc.contributor.authorHayashizaki, Yoshihide
dc.date.accessioned2017-05-03T15:23:15Z
dc.date.available2017-05-03T15:23:15Z
dc.date.issued2009
dc.identifier.issn1061-4036
dc.identifier.doi10.1038/ng.375
dc.identifier.urihttp://hdl.handle.net/10072/28583
dc.description.abstractUsing deep sequencing (deepCAGE), the FANTOM4 study measured the genome-wide dynamics of transcription-start-site usage in the human monocytic cell line THP-1 throughout a time course of growth arrest and differentiation. Modeling the expression dynamics in terms of predicted cis-regulatory sites, we identified the key transcription regulators, their time-dependent activities and target genes. Systematic siRNA knockdown of 52 transcription factors confirmed the roles of individual factors in the regulatory network. Our results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom553
dc.relation.ispartofpageto562
dc.relation.ispartofissue5
dc.relation.ispartofjournalNature Genetics
dc.relation.ispartofvolume41
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310509
dc.subject.fieldofresearchcode32
dc.titleThe transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-31T22:20:57Z
gro.hasfulltextNo Full Text
gro.griffith.authorMatigian, Nicholas
gro.griffith.authorWells, Christine
gro.griffith.authorBeckhouse, Anthony G.
gro.griffith.authorChalk, Alistair M.
gro.griffith.authorForrest, Alistair RR.
gro.griffith.authorCloonan, Nicole
gro.griffith.authorQuackenbush, John


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