Inhibition effect of Jagged1 protein on differentiation of neural stem cells into neurons
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Objective : To investigate the effects of Jagged1 protein on the differentiation of neural stem cells. Methods : Neural stem cells were isolated from mouse embryonic brain and cultured in vitro. After the neural stem cells were identified , Jagged1 protein was used to induce the differentiation of the neural progenitor cells and the number of differentiated neurons was counted. Results : The cultured cells could proliferate and differentiate into neurons , astrocytes and oligodendrocytes. After Jagged1 protein treatment the number of neurons in differentiated cells decreased compared with that in control group , which could be counteracted by gamma-secretase inhibitor. Conclusion : Neural stem cells are self-renewal , multipotent and can express Notch receptor. Jagged1 protein can inhibit neural stem cells differentiation into neuron through Notch signaling pathway.
Chinese Journal of Anatomy
Biochemistry and Cell Biology not elsewhere classified