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dc.contributor.authorHolmes, Roger S
dc.contributor.authorGoldberg, Erwin
dc.date.accessioned2017-05-03T16:59:12Z
dc.date.available2017-05-03T16:59:12Z
dc.date.issued2009
dc.date.modified2010-10-13T09:59:18Z
dc.identifier.issn1476-9271
dc.identifier.doi10.1016/j.compbiolchem.2009.07.006
dc.identifier.urihttp://hdl.handle.net/10072/29281
dc.description.abstractComputational methods were used to predict the amino acid sequences and gene locations for mammalian lactate dehydrogenase (LDH) genes and proteins using genome sequence databanks.HumanLDHA, LDHC and LDH6A genes were located in tandem on chromosome 11, while LDH6B and LDH6C genes were on chromosomes 15 and 12, respectively. Opossum LDHC and LDH6B genes were located in tandem with the opossum LDHA gene on chromosome 5 and contained 7 (LDHA and LDHC) or 8 (LDH6B) exons. An amino acid sequence prediction for the opossum LDH6B subunit gave an extended N-terminal sequence, similar to the human and mouse LDH6B sequences, which may support the export of this enzyme into mitochondria. The platypus genome contained at least 3 LDH genes encoding LDHA, LDHB and LDH6B subunits. Phylogenetic studies and sequence analyses indicated that LDHA, LDHB and LDH6B genes are present in all mammalian genomes examined, including a monotreme species (platypus), whereas the LDHC gene may have arisen more recently in marsupial mammals.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent328794 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom379
dc.relation.ispartofpageto385
dc.relation.ispartofissue5
dc.relation.ispartofjournalComputational Biology and Chemistry
dc.relation.ispartofvolume33
dc.rights.retentionY
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchInformation and Computing Sciences
dc.subject.fieldofresearchcode060408
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode08
dc.titleComputational analyses of mammalian lactate dehydrogenases: Human, mouse, opossum and platypus LDHs
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorHolmes, Roger S.


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