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dc.contributor.authorWoledge, R.en_US
dc.contributor.authorBarclay, Chrisen_US
dc.contributor.authorCurtin, N.en_US
dc.date.accessioned2017-05-03T11:39:56Z
dc.date.available2017-05-03T11:39:56Z
dc.date.issued2009en_US
dc.date.modified2010-08-24T06:50:02Z
dc.identifier.issn09628452en_US
dc.identifier.doi10.1098/rspb.2009.0177en_AU
dc.identifier.urihttp://hdl.handle.net/10072/29282
dc.description.abstractFollowing the ideas introduced by Huxley (Huxley 1957, Prog. Biophys. Biophys. Chem. 7, 255-318), it is generally supposed that muscle contraction is produced by temporary links, called crossbridges, between myosin and actin filaments, which form and break in a cyclic process driven by ATP splitting. Here we consider the interaction of the energy in the crossbridge, in its various states, and the force exerted. We discuss experiments in which the mechanical state of the crossbridge is changed by imposed movement and the energetic consequence observed as heat output and the converse experiments in which the energy content is changed by altering temperature and the mechanical consequences are observed. The thermodynamic relationship between the experiments is explained and, at the first sight, the relationship between the results of these two types of experiment appears paradoxical. However, we describe here how both of them can be explained by a model in which mechanical and energetic changes in the crossbridges occur in separate steps in a branching cycle.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherRoyal Society Publishingen_US
dc.publisher.placeLondonen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom2685en_US
dc.relation.ispartofpageto2695en_US
dc.relation.ispartofjournalProceedings of the Royal Society of London, Series B: Biological Sciencesen_US
dc.relation.ispartofvolume276en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchAnimal Physiology - Biophysicsen_US
dc.subject.fieldofresearchcode060601en_US
dc.titleTemperature change as a probe of muscle crossbridge kinetics: a review and discussionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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