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  • Bovine carboxylesterases: Evidence for two CES1 and five families of CES genes on chromosome 18

    Author(s)
    Holmes, Roger S
    Cox, Laura A
    VandeBerg, John L
    Griffith University Author(s)
    Holmes, Roger S.
    Year published
    2009
    Metadata
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    Abstract
    Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical. Two forms of CES1.2 were also observed apparently caused by an indel polymorphism encoded at the C-terminus end. Two CES gene clusters were observed on chromosome 18: CES5-CES1.1-CES1.2 and CES2-CES3-CES6. Bovine CES1, CES2, CES3, CES5 and CES6 shared 39-45% identity with each other, but showed 71-76% identity with each of the five corresponding human CES family members. ...
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    Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical. Two forms of CES1.2 were also observed apparently caused by an indel polymorphism encoded at the C-terminus end. Two CES gene clusters were observed on chromosome 18: CES5-CES1.1-CES1.2 and CES2-CES3-CES6. Bovine CES1, CES2, CES3, CES5 and CES6 shared 39-45% identity with each other, but showed 71-76% identity with each of the five corresponding human CES family members. Phylogeny studies indicated that bovine CES genes originated from five ancestral gene duplication events which predated the eutherian mammalian common ancestor. In addition, a subsequent CES1 gene duplication event is proposed during mammalian evolution prior to the appearance of the Bovidae common ancestor ~ 20 MY ago.
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    Journal Title
    Comparative Biochemistry and Physiology, Part D
    Volume
    4
    Issue
    1
    Publisher URI
    http://www.sciencedirect.com/science/journal/1744117X
    DOI
    https://doi.org/10.1016/j.cbd.2008.09.002
    Subject
    Genetics
    Genomics
    Publication URI
    http://hdl.handle.net/10072/29319
    Collection
    • Journal articles

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