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dc.contributor.authorBei, Weijian
dc.contributor.authorZang, Linquan
dc.contributor.authorGuo, Jiao
dc.contributor.authorPeng, Wenlie
dc.contributor.authorXu, Anlong
dc.contributor.authorGood, David A
dc.contributor.authorHu, Yinming
dc.contributor.authorWu, Wei
dc.contributor.authorHu, Dehui
dc.contributor.authorZhu, Xinghong
dc.contributor.authorWei, Ming
dc.contributor.authorLi, Chuyuan
dc.date.accessioned2017-05-03T13:02:12Z
dc.date.available2017-05-03T13:02:12Z
dc.date.issued2009
dc.date.modified2010-06-24T05:22:05Z
dc.identifier.issn0378-8741
dc.identifier.doi10.1016/j.jep.2009.07.034
dc.identifier.urihttp://hdl.handle.net/10072/29512
dc.description.abstractEthnopharmacological relevance: Flavonoids, extracted from the leaves of Diospyros kaki, are the main therapeutic components of NaoXingQing (NXQ), a potent and patented Chinese herbal remedy widely used in China for the treatment of apoplexy syndrome. Aim of the study: To investigate the neuroprotective effects of FLDK-P70, a standardized flavonoid extract, using in vivo rat models of both focal ischemia/reperfusion (I/R) injury induced by middle cerebral artery occlusion (MCAO) and on transient global brain ischemia induced by four-vessel occlusion (4-VO). We also aim to examine the effects of FLDK-P70 on glutamate-induced cell injury of hippocampal neurons as well as on hypoxia-induced injury of cortical neurons in primary cell culture. Materials and methods and results: Administration of FLDK-P70 for 12 days (40, 80 mg/kg body weight, p.o., 5 days before and 7 days after 4-VO) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. Similarly, administration of FLDK-P70 for 7 days (40, 80 mg/kg body weight, p.o., 3 days before and 4 days after MCAO) significantly reduced the lesion of the insulted brain hemisphere and improved the neurological behavior of rats. In primary rat hippocampal neuronal cultures, pretreatment with FLDK-P70 (5, 10 g/ml) protected neurons from glutamate-induced excitotoxic neuronal death in a dose-dependent manner. In primary rat cerebral cortical neuronal culture, pretreatment with FLDK-P70 (25, 100 g/ml) also reduced hypoxia-reoxygen induced neuronal death and apoptosis in a dose-dependent manner. Conclusions: These in vivo and in vitro results suggest that FLDK-P70 significantly protects rats fromMCAO and 4-VO ischemic injury in vivo and protects hippocampal neurons from glutamate-induced excitotoxic injury as well as cortical neurons from hypoxia-induced injury in vitro. The mechanisms of these effects may be due to the antioxidative activity of the flavonoids. These results convincingly demonstrate that FLDK-P70 may be useful for the prevention and treatment of ischemia/reperfusion injury and other related neurodegenerative diseases.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom134
dc.relation.ispartofpageto142
dc.relation.ispartofjournalJournal of Ethnopharmacology
dc.relation.ispartofvolume126
dc.rights.retentionY
dc.subject.fieldofresearchPlant biology
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchTraditional Chinese medicine and treatments
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3108
dc.subject.fieldofresearchcode4208
dc.subject.fieldofresearchcode420803
dc.subject.fieldofresearchcode3214
dc.titleNeuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorWei, Ming Q.


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