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dc.contributor.authorEgger, Sam
dc.contributor.authorPetoumenos, Kathy
dc.contributor.authorKamarulzaman, Adeeba
dc.contributor.authorHoy, Jennifer
dc.contributor.authorSungkanuparph, Somnuek
dc.contributor.authorChuah, John
dc.contributor.authorFalster, Kathleen
dc.contributor.authorZhou, Jialun
dc.contributor.authorG. Law, Matthew
dc.date.accessioned2017-05-03T14:18:39Z
dc.date.available2017-05-03T14:18:39Z
dc.date.issued2009
dc.date.modified2010-05-21T06:35:43Z
dc.identifier.issn15254135
dc.identifier.doi10.1097/QAI.0b013e31819906d3
dc.identifier.urihttp://hdl.handle.net/10072/29762
dc.description.abstractBackground: Random effects models were used to explore how the shape of CD4 cell count responses after commencing combination antiretroviral therapy (cART) develop over time and, in particular, the role of baseline and follow-up covariates. Methods: Patients in Asia Pacific HIV Observational Database who first commenced cART after January 1, 1997, and who had a baseline CD4 cell count and viral load measure and at least 1 follow-up measure between 6 and 24 months, were included. CD4 cell counts were determined at every 6-month period after the commencement of cART for up to 6 years. Results: A total of 1638 patients fulfilled the inclusion criteria with a median follow-up time of 58 months. Lower post-cART mean CD4 cell counts were found to be associated with increasing age (P < 0.001), pre-cART hepatitis C coinfection (P = 0.038), prior AIDS (P = 0.019), baseline viral load =100,000 copies per milliliter (P < 0.001), and the Asia Pacific region compared with Australia (P = 0.005). A highly significant 3-way interaction between the effects of time, baseline CD4 cell count, and post-cART viral burden (P < 0.0001) was demonstrated. Higher long-term mean CD4 cell counts were associated with lower baseline CD4 cell count and consistently undetectable viral loads. Among patients with consistently detectable viral load, CD4 cell counts seemed to converge for all baseline CD4 levels. Conclusions: Our analyses suggest that the long-term shape of post-cART CD4 cell count changes depends only on a 3-way interaction between baseline CD4 cell count, viral load response, and time.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.publisher.urihttps://journals.lww.com/jaids/pages/results.aspx?txtKeywords=Long-Term+Patterns+in+CD4+Response+Are+Determined+by+an+Interaction+Between+Baseline+CD4+Cell+Count%2c+Viral+Load%2c+and+Time%3a+The+Asia+Pacific+HIV+Observational+Database+(APHOD)
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom513
dc.relation.ispartofpageto520
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal Acquired Immune Deficiency Syndrome
dc.relation.ispartofvolume50
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleLong-Term Patterns in CD4 Response Are Determined by an Interaction Between Baseline CD4 Cell Count, Viral Load, and Time: The Asia Pacific HIV Observational Database (APHOD)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorChuah, John


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