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dc.contributor.authorReichhold, Stefanieen_US
dc.contributor.authorNeubauer, Oliveren_US
dc.contributor.authorBulmer, Andrewen_US
dc.contributor.authorKnasmuller, Siegfrieden_US
dc.contributor.authorWagner, Karl-Heinzen_US
dc.date.accessioned2017-05-03T15:40:13Z
dc.date.available2017-05-03T15:40:13Z
dc.date.issued2009en_US
dc.date.modified2010-05-21T06:36:22Z
dc.identifier.issn13835742en_US
dc.identifier.doi10.1016/j.mrrev.2009.02.002en_AU
dc.identifier.urihttp://hdl.handle.net/10072/29773
dc.description.abstractIt is commonly accepted that regular moderate intensity physical activity reduces the risk of developing many diseases. Counter intuitively, however, evidence also exists for oxidative stress resulting from acute and strenuous exercise. Enhanced formation of reactive oxygen and nitrogen species may lead to oxidatively modified lipids, proteins and nucleic acids and possibly disease. Currently, only a few studies have investigated the influence of exercise on DNA stability and damage with conflicting results, small study groups and the use of different sample matrices or methods and result units. This is the first review to address the effect of exercise of various intensities and durations on DNA stability, focusing on human population studies. Furthermore, this article describes the principles and limitations of commonly used methods for the assessment of oxidatively modified DNA and DNA stability. This review is structured according to the type of exercise conducted (field or laboratory based) and the intensity performed (i.e. competitive ultra/endurance exercise or maximal tests until exhaustion). The findings presented here suggest that competitive ultra-endurance exercise (>4 h) does not induce persistent DNA damage. However, when considering the effects of endurance exercise (<4 h), no clear conclusions could be drawn. Laboratory studies have shown equivocal results (increased or no oxidative stress) after endurance or exhaustive exercise. To clarify which components of exercise participation (i.e. duration, intensity and training status of subjects) have an impact on DNA stability and damage, additional carefully designed studies combining the measurement of DNA damage, gene expression and DNA repair mechanisms before, during and after exercise of differing intensities and durations are required.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/13835742en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom28en_US
dc.relation.ispartofpageto38en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalMutation Researchen_US
dc.relation.ispartofvolume682en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMolecular Targetsen_US
dc.subject.fieldofresearchExercise Physiologyen_US
dc.subject.fieldofresearchcode111207en_US
dc.subject.fieldofresearchcode110602en_US
dc.titleEndurance exercise and DNA stability: is there a link to duration and intensity?en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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