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dc.contributor.authorDawe, Sharon
dc.contributor.authorDavis, Penelope
dc.contributor.authorLapworth, Kely
dc.contributor.authorMcKetin, Rebecca
dc.date.accessioned2017-05-03T15:52:29Z
dc.date.available2017-05-03T15:52:29Z
dc.date.issued2009
dc.date.modified2010-05-21T06:36:32Z
dc.identifier.issn0951-7367
dc.identifier.doi10.1097/YCO.0b013e32832a1dd4
dc.identifier.urihttp://hdl.handle.net/10072/29775
dc.description.abstractPURPOSE OF REVIEW: To review current evidence linking amphetamine use with aggression and to consider possible factors that might underlie this association. RECENT FINDINGS: Although evidence that amphetamine use is related to increased levels of aggression continues to grow, the underlying processes or mechanisms remain somewhat elusive. In this review, three possible underlying factors are considered. Neurotoxic, pharmacological effects of amphetamine on the dopaminergic and serotonergic systems are related to aggressive, hostile behavior in both animal and human studies. Of particular interest is the converging evidence that amphetamine use is related to impairment in executive functions (including self-control) that are regulated by the prefrontal cortex. Taken together, these findings suggest that amphetamine users may have an impaired capacity to control or inhibit aggressive impulses. Furthermore, high levels of impulsivity related to amphetamine use may also play a role. Finally, amphetamine use is associated with increased positive symptoms of psychosis, particularly paranoia, that contribute to a perception of the environment as a hostile, threatening place. SUMMARY: Taken separately, each of these factors may lead to an increase in aggression with increased use of amphetamine, but their interactive or synergistic effects may be particularly problematic.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.publisher.urihttp://journals.lww.com/co-psychiatry/pages/default.aspx
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom269
dc.relation.ispartofpageto273
dc.relation.ispartofissue3
dc.relation.ispartofjournalCurrent Opinion in Psychiatry
dc.relation.ispartofvolume22
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1702
dc.titleMechanisms underlying aggressive and hostile behavior in amphetamine users
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Applied Psychology
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorDavis, Penelope J.
gro.griffith.authorDawe, Sharon
gro.griffith.authorLapworth, Kely


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