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dc.contributor.authorDawe, Sharonen_US
dc.contributor.authorDavis, Penelopeen_US
dc.contributor.authorLapworth, Kelyen_US
dc.contributor.authorMcKetin, Rebeccaen_US
dc.date.accessioned2017-05-03T15:52:29Z
dc.date.available2017-05-03T15:52:29Z
dc.date.issued2009en_US
dc.date.modified2010-05-21T06:36:32Z
dc.identifier.issn09517367en_US
dc.identifier.doi10.1097/YCO.0b013e32832a1dd4en_AU
dc.identifier.urihttp://hdl.handle.net/10072/29775
dc.description.abstractPURPOSE OF REVIEW: To review current evidence linking amphetamine use with aggression and to consider possible factors that might underlie this association. RECENT FINDINGS: Although evidence that amphetamine use is related to increased levels of aggression continues to grow, the underlying processes or mechanisms remain somewhat elusive. In this review, three possible underlying factors are considered. Neurotoxic, pharmacological effects of amphetamine on the dopaminergic and serotonergic systems are related to aggressive, hostile behavior in both animal and human studies. Of particular interest is the converging evidence that amphetamine use is related to impairment in executive functions (including self-control) that are regulated by the prefrontal cortex. Taken together, these findings suggest that amphetamine users may have an impaired capacity to control or inhibit aggressive impulses. Furthermore, high levels of impulsivity related to amphetamine use may also play a role. Finally, amphetamine use is associated with increased positive symptoms of psychosis, particularly paranoia, that contribute to a perception of the environment as a hostile, threatening place. SUMMARY: Taken separately, each of these factors may lead to an increase in aggression with increased use of amphetamine, but their interactive or synergistic effects may be particularly problematic.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLippincott Williams & Wilkinsen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://journals.lww.com/co-psychiatry/pages/default.aspxen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom269en_US
dc.relation.ispartofpageto273en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalCurrent Opinion in Psychiatryen_US
dc.relation.ispartofvolume22en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchClinical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode110399en_US
dc.titleMechanisms underlying aggressive and hostile behavior in amphetamine usersen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Applied Psychologyen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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