Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma

View/ Open
Author(s)
Green, Michael
Gandhi, Maher
Courtney, Mark
Marlton, Paula
Griffiths, Lyn
Year published
2009
Metadata
Show full item recordAbstract
FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as ...
View more >FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.
View less >
View more >FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.
View less >
Journal Title
Leukemia Research
Volume
33
Issue
12
Publisher URI
Copyright Statement
© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Gene Expression (incl. Microarray and other genome-wide approaches)
Clinical Sciences