Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma
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FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.
© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Gene Expression (incl. Microarray and other genome-wide approaches)