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  • Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma

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    Author(s)
    Green, Michael
    Gandhi, Maher
    Courtney, Mark
    Marlton, Paula
    Griffiths, Lyn
    Griffith University Author(s)
    Griffiths, Lyn
    Green, Michael R.
    Gandhi, Maher K.
    Courtney, Mark
    Year published
    2009
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    Abstract
    FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as ...
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    FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.
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    Journal Title
    Leukemia Research
    Volume
    33
    Issue
    12
    Publisher URI
    http://www.sciencedirect.com/science/journal/01452126
    DOI
    https://doi.org/10.1016/j.leukres.2009.05.004
    Copyright Statement
    © 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Gene Expression (incl. Microarray and other genome-wide approaches)
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/29813
    Collection
    • Journal articles

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