Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma

Abstract

FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.