• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis

    Thumbnail
    View/Open
    57735_1.pdf (78.07Kb)
    Author(s)
    Cervin, Anders
    Wallwork, Ben
    Mackay-Sim, Alan
    Coman, William B
    Greiff, Lennart
    Griffith University Author(s)
    Mackay-Sim, Alan
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 姠ml-1) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), ...
    View more >
    Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 姠ml-1) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), myeloperoxidase (MPO), eosinophil cationic protein (ECP), a2-macroglobulin and fucose were monitored as indices of pro-inflammatory cytokine production, neutrophil and eosinophil granulocyte activities, plasma exudation and mucinous secretion, respectively. Clarithromycin reduced the lavage fluid levels of IL-8 at the low-dose histamine observation (P<0簰1). There was a trend towards reduced MPO by the treatment, whereas ECP was significantly reduced at the low-dose histamine observation (P<0簵). a2-Macroglobulin was reduced by clarithromycin (saline lavages) (P = 0簵), whereas fucose was unaffected. The exudative responsiveness to high-dose histamine was significantly reduced by the treatment (P<0簵). Furthermore, significantly lower levels of fucose were observed at the low-dose histamine observation (P<0簱). We conclude that long-term clarithromycin treatment likely exerts an anti-inflammatory effect in CRS.
    View less >
    Journal Title
    Clinical Physiology and Functional Imaging
    Volume
    29
    Issue
    2
    Publisher URI
    http://www.wiley.com/bw/journal.asp?ref=1475-0961&site=1
    DOI
    https://doi.org/10.1111/j.1475-097X.2008.00848.x
    Copyright Statement
    © 2009 Scandinavian Society of Clinical Physiology and Nuclear Medicine. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. The definitive version is available at www.interscience.wiley.com
    Subject
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/29821
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander