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dc.contributor.authorJ. Gauci, Victoriaen_US
dc.contributor.authorBeckhouse, Anthonyen_US
dc.contributor.authorLyons, Victoriaen_US
dc.contributor.authorJ. Beh, Ericen_US
dc.contributor.authorJ. Rogers, Peteren_US
dc.contributor.authorW. Dawes, Ianen_US
dc.contributor.authorJ. Higgins, Vincenten_US
dc.date.accessioned2017-04-24T12:50:21Z
dc.date.available2017-04-24T12:50:21Z
dc.date.issued2009en_US
dc.date.modified2010-05-25T07:49:29Z
dc.identifier.issn15671356en_US
dc.identifier.doi10.1111/j.1567-1364.2009.00557.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/29828
dc.description.abstractDuring the production of wine and beer, the yeast Saccharomyces cerevisiae can encounter an environment that is deficient in zinc, resulting in a 'sluggish' or a 'stuck' ferment. It has been shown that the Zap1p-transcription factor induces the expression of a regulon in response to zinc deficiency; however, it was evident that a separate regulon was also activated during zinc deficiency in a Zap1p-independent manner. This study discovered the Msn2p and Msn4p (Msn2/4p) transcriptional activator proteins to be an additional control mechanism inducing the stress response during zinc deficiency. Promoter sequence analysis identified the stress response element (STRE) motif, recognized by Msn2/4p, and was significantly enriched in the promoters of genes induced by zinc deficiency. An investigation using genome-wide analyses revealed a distinct regulon consisting of STREcontaining genes whose zinc-responsive expression was abolished in an msn2 msn4 double mutant. An STRE-driven lacZ reporter construct confirmed that expression of the genes within this regulon was perturbed by the deletion of MSN2 and MSN4 and also implicated Hog1p as a contributing factor. This research provides a better understanding of the molecular mechanisms involved in the yeast response to zinc deficiency during fermentation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBlackwell Publishing Ltd.en_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://www.wiley.com/bw/journal.asp?ref=1567-1356en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1187en_US
dc.relation.ispartofpageto1195en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalFEMS Yeast Researchen_US
dc.relation.ispartofvolume9en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchGenomicsen_US
dc.subject.fieldofresearchcode060408en_US
dc.titleZinc starvation induces a stress response in Saccharomyces cerevisiae that is mediated by the Msn2p and Msn4p transcriptional activatorsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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