Show simple item record

dc.contributor.authorRamli, Rosalina
dc.contributor.authorReher, Peter
dc.contributor.authorHarris, Malcolm
dc.contributor.authorMeghji, Sajeda
dc.date.accessioned2017-05-03T15:40:34Z
dc.date.available2017-05-03T15:40:34Z
dc.date.issued2009
dc.date.modified2010-06-02T09:47:00Z
dc.identifier.issn08822786
dc.identifier.urihttp://hdl.handle.net/10072/29971
dc.description.abstractPURPOSE: Ultrasound therapy induces clinical healing of irradiated avascular mandibular bone and fractures. In vitro ultrasound in tissue culture has been shown to stimulate bone formation synthesis and bone remodeling factors and to stimulate osteoblast proliferation. Therefore, the aim of the present study was to investigate the effect of short-wave (1-MHz) and long-wave (45-kHz) ultrasound on the vascularity of the chorioallantoic membrane (CAM) of a fertilized egg. MATERIALS AND METHODS: The nature of the angiogenic effect was investigated using the CAM of a fertilized egg by: (1) application of sonicated fibroblast media incorporated into methylcellulose disks onto the CAM and (2) direct application of the ultrasound, using both long-wave (45-kHz) and short-wave (1-MHz) frequencies at a range of intensities, to the surface of the egg. Angiogenesis was assessed quantitatively by three independent observers. RESULTS: Both ultrasound methods showed evidence of an angiogenic effect compared to controls. The most effective results were seen with direct application of a 45-kHz wave at an intensity of 15 mW/cm(2) and indirect application of the media of fibroblasts ultrasonicated at 1 MHz with an intensity of 0.4 W/cm(2). CONCLUSION: This model confirms that ultrasound can induce neoangiogenesis in vivo.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent168710 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherQuintessence Publishing Co., Inc.
dc.publisher.placeUnited States
dc.publisher.urihttp://www.quintpub.com/journals/omi/full_txt_pdf_alert.php?article_id=4626
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom591
dc.relation.ispartofpageto596
dc.relation.ispartofissue4
dc.relation.ispartofjournalInternational Journal of Oral & Maxillofacial Implants
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOral and maxillofacial surgery
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320305
dc.titleThe Effect of Ultrasound on Angiogenesis: An In Vivo Study Using the Chick Chorioallantoic Membrane
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 Quintessence Publishing Co. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorReher, Peter


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record