Antimalarial Activity of Azafluorenone Alkaloids from the Australian Tree Mitrephora diversifolia
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Mass-directed isolation of the CH2Cl2/MeOH extract from the roots of the Australian tree Mitrephora diVersifolia resulted in the purification of the new azafluorenone alkaloid 5,8-dihydroxy-6-methoxyonychine (1) together with the known natural product 5-hydroxy-6-methoxyonychine (2). The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 2 displayed IC50 values of 9.9 and 11.4 卬 respectively, while 1 showed minimal activity.
Journal of Natural Products
Copyright 2009 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Biologically Active Molecules