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dc.contributor.authorBuchanan, Malcolm S
dc.contributor.authorDavis, Rohan A
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2021-07-26T23:44:18Z
dc.date.available2021-07-26T23:44:18Z
dc.date.issued2009
dc.date.modified2010-06-04T05:14:39Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np9002564
dc.identifier.urihttp://hdl.handle.net/10072/30022
dc.description.abstractMass-directed isolation of the CH2Cl2/MeOH extract of Doryphora sassafras resulted in the purification of a new benzylisoquinoline alkaloid, 1-(4-hydroxybenzyl)-6,7-methylenedioxy-2-methylisoquinolinium trifluoroacetate (1), and the known aporphine alkaloid (S)-isocorydine (2). The structures of 1 and 2 were determined by 1D and 2D NMR and MS data analyses. The compounds were isolated during a drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 1 displayed IC50 values of 3.0 and 4.4 μM, respectively. Compound 1 was tested for cytotoxicity toward a human embryonic kidney cell line (HEK293) and displayed no activity at 120 μM.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS Publications)
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1541
dc.relation.ispartofpageto1543
dc.relation.ispartofissue8
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume72
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleAntimalarial Benzylisoquinoline Alkaloid from the Rainforest Tree Doryphora sassafras
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2009 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np9002564
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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