Clavatadines C-E, Guanidine Alkaloids from the Australian Sponge Suberea clavata

Author
Buchanan, Malcolm
Carroll, Anthony
Wessling, Deborah
Jobling, Michael
Avery, Vicky
Davis, Rohan
Feng, Yun
Quinn, Ronald
Year published
2009
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Abstract
Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea claVata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
Journal Title
Journal of Natural Products
Volume
72
Issue
5
DOI
Copyright Statement
© 2009 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Subject
Biochemistry and Cell Biology not elsewhere classified
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