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  • Clavatadines C-E, Guanidine Alkaloids from the Australian Sponge Suberea clavata

    Author(s)
    Buchanan, Malcolm S
    Carroll, Anthony R
    Wessling, Deborah
    Jobling, Michael
    Avery, Vicky M
    Davis, Rohan A
    Feng, Yunjiang
    Hooper, John NA
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Davis, Rohan A.
    Carroll, Anthony R.
    Avery, Vicky M.
    Feng, Yun J.
    Year published
    2009
    Metadata
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    Abstract
    Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea claVata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea claVata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
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    Journal Title
    Journal of Natural Products
    Volume
    72
    Issue
    5
    DOI
    https://doi.org/10.1021/np8008013
    Subject
    Chemical sciences
    Biological sciences
    Biochemistry and cell biology not elsewhere classified
    Biomedical and clinical sciences
    Traditional, complementary and integrative medicine
    Publication URI
    http://hdl.handle.net/10072/30023
    Collection
    • Journal articles

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