Flinderoles A-C: Antimalarial Bis-indole  Alkaloids from Flindersia Species

Fernandez, Liza S; Buchanan, Malcolm S; Carroll, Anthony R; Feng, Yun Jiang; Quinn, Ronald J; Avery, Vicky M

doi:10.1021/ol802506n

Author(s)

Fernandez, Liza S

Buchanan, Malcolm S

Carroll, Anthony R

Feng, Yun Jiang

Quinn, Ronald J

Avery, Vicky M

Griffith University Author(s)

Year published

2009

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Abstract

With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC50 values between 0.15-1.42 卮 Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC50 values between 0.15-1.42 卮 Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
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Journal Title

Organic Letters

Volume

Issue

DOI

https://doi.org/10.1021/ol802506n

Copyright Statement

© 2009 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.

Subject

Chemical sciences

Biochemistry and cell biology not elsewhere classified

Publication URI

http://hdl.handle.net/10072/30024

Collection

Journal articles