Guttiferones O and P, Prenylated Benzophenone MAPKAPK-2 Inhibitors from Garcinia solomonensis
Author(s)
Carroll, Anthony R
Suraweera, Lekha
King, Gordon
Rali, Topul
Quinn, Ronald J
Year published
2009
Metadata
Show full item recordAbstract
Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative con?gurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC50 values of 22.0 卮Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative con?gurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC50 values of 22.0 卮
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Journal Title
Journal of Natural Products
Volume
72
Issue
9
Copyright Statement
© 2009 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine