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  • Insights into the Structure, Function, and Regulation of Human Cytochrome P450 1A2

    Author(s)
    Zhou, Shu-Feng
    Yang, Li-Ping
    Wei, Ming Qian
    Duan, Wei
    Chan, Eli
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2009
    Metadata
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    Abstract
    CYP1A2 is one of the major CYPs in human liver (~13%) and metabolises a variety of clinically important drugs, such as clozapine, lidocaine, theophylline, tacrine, and leflunomide. CYP1A2 is one of the major enzymes that bioactivate a number of procarcinogens and thus induction of CYP1A2 may increase the carcinogenicity of these compounds. This enzyme also metabolizes several important endogenous compounds including steroids, retinols, melatonin, uroporphyrinogen and arachidonic acid. In the recently published crystal structure of CYP1A2 in complex with a-naphthoflavone, its compact active site is closed without clear solvent ...
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    CYP1A2 is one of the major CYPs in human liver (~13%) and metabolises a variety of clinically important drugs, such as clozapine, lidocaine, theophylline, tacrine, and leflunomide. CYP1A2 is one of the major enzymes that bioactivate a number of procarcinogens and thus induction of CYP1A2 may increase the carcinogenicity of these compounds. This enzyme also metabolizes several important endogenous compounds including steroids, retinols, melatonin, uroporphyrinogen and arachidonic acid. In the recently published crystal structure of CYP1A2 in complex with a-naphthoflavone, its compact active site is closed without clear solvent or substrate access channels. Not surprisingly, CYP1A2 has a relatively small volume of the active site cavity of 375 ų, which is 44.2% larger than that of CYP2A6 (260 ų), but much smaller than that of CYP3A4 (1385 ų) and 2C8 (1438 ų). Generally, CYP1A2 substrates contain planar ring that can fit the narrow and planar active site of the enzyme. Like many of other CYPs, CYP1A2 is subject to induction and inhibition by a number of compounds. Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (ŨR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors. Knockout of Cyp1a2 in mice has provided a very useful tool for the functional investigation of this gene. Further studies are needed to explore the clinical and toxicological significance of CYP1A2.
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    Journal Title
    Current Drug Metabolism
    Volume
    10
    Issue
    7
    Publisher URI
    http://www.benthamdirect.org/pages/content.php?CDM/2009/00000010/00000007/0005F.SGM
    Subject
    Clinical Sciences not elsewhere classified
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/30217
    Collection
    • Journal articles

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