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dc.contributor.authorGardiner, Donald L
dc.contributor.authorSkinner-Adams, Tina S
dc.contributor.authorBrown, Christopher L
dc.contributor.authorAndrews, Katherine T
dc.contributor.authorStack, Colin M
dc.contributor.authorMcCarthy, James S
dc.contributor.authorDalton, John P
dc.contributor.authorTrenholme, Katharine R
dc.date.accessioned2017-05-03T11:45:21Z
dc.date.available2017-05-03T11:45:21Z
dc.date.issued2009
dc.date.modified2010-11-03T07:04:15Z
dc.identifier.issn1478-7210
dc.identifier.doi10.1586/eri.09.93
dc.identifier.urihttp://hdl.handle.net/10072/30257
dc.description.abstractMalaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent3906984 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherExpert Reviews Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1087
dc.relation.ispartofpageto1098
dc.relation.ispartofissue9
dc.relation.ispartofjournalExpert Reviews of Anti-Infective Therapy
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titlePlasmodium falciparum: new molecular targets with potential for antimalarial drug development
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 Expert Reviews Ltd.. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorAndrews, Katherine T.
gro.griffith.authorSkinner-Adams, Tina


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