dc.contributor.author | Gardiner, Donald L | |
dc.contributor.author | Skinner-Adams, Tina S | |
dc.contributor.author | Brown, Christopher L | |
dc.contributor.author | Andrews, Katherine T | |
dc.contributor.author | Stack, Colin M | |
dc.contributor.author | McCarthy, James S | |
dc.contributor.author | Dalton, John P | |
dc.contributor.author | Trenholme, Katharine R | |
dc.date.accessioned | 2017-05-03T11:45:21Z | |
dc.date.available | 2017-05-03T11:45:21Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2010-11-03T07:04:15Z | |
dc.identifier.issn | 1478-7210 | |
dc.identifier.doi | 10.1586/eri.09.93 | |
dc.identifier.uri | http://hdl.handle.net/10072/30257 | |
dc.description.abstract | Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 3906984 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Expert Reviews Ltd. | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1087 | |
dc.relation.ispartofpageto | 1098 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | Expert Reviews of Anti-Infective Therapy | |
dc.relation.ispartofvolume | 7 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.title | Plasmodium falciparum: new molecular targets with potential for antimalarial drug development | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2009 Expert Reviews Ltd.. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 2009 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Andrews, Katherine T. | |
gro.griffith.author | Skinner-Adams, Tina | |