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  • Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

    Author
    N.W. Dissanayaka, Nadeeka
    A. Silburn, Peter
    D. O⿿Sullivan, John
    Mellick, George
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter ...
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    Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.
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    Journal Title
    Movement Disorders
    Volume
    24
    Issue
    1
    DOI
    https://doi.org/10.1002/mds.22134
    Copyright Statement
    © 2009 Movement Disorders Society. Published by John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by the Movement Disorders Society. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Neurology and Neuromuscular Diseases
    Publication URI
    http://hdl.handle.net/10072/30302
    Collection
    • Journal articles

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