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  • Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis

    Author(s)
    Zobalova, Renata
    Stantic, Marina
    Prokopova, Katerina
    Dong, Lan-Feng
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Zobalova, Renata
    Stantic, Marina
    Dong, Lan-feng
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    It is increasingly accepted that cancer stem cells (CSCs) are rather resistant to apoptosis to various inducers, including the immunological apoptogen TRAIL. Here we show that cancer cells with high expression of CD133, a marker that is often associated with CSCs, are resistant to TRAIL-induced apoptosis, compared to their CD133-low counterparts. We show that this resistance can be ascribed to the high expression of FLIP, an inhibitor of the extrinsic apoptotic pathway, in CD133-high cells. Downregulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL ...
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    It is increasingly accepted that cancer stem cells (CSCs) are rather resistant to apoptosis to various inducers, including the immunological apoptogen TRAIL. Here we show that cancer cells with high expression of CD133, a marker that is often associated with CSCs, are resistant to TRAIL-induced apoptosis, compared to their CD133-low counterparts. We show that this resistance can be ascribed to the high expression of FLIP, an inhibitor of the extrinsic apoptotic pathway, in CD133-high cells. Downregulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP.
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    Journal Title
    BioFactors
    Volume
    34
    Issue
    3
    DOI
    https://doi.org/10.1002/biof.5520340307
    Subject
    Biochemistry and cell biology
    Animal cell and molecular biology
    Cancer cell biology
    Publication URI
    http://hdl.handle.net/10072/30306
    Collection
    • Journal articles

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