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dc.contributor.authorR. Sohrabi, Hamiden_US
dc.contributor.authorA. Bates, Kristynen_US
dc.contributor.authorRodrigues, Marken_US
dc.contributor.authorTaddei, Kevinen_US
dc.contributor.authorM. Laws, Simonen_US
dc.contributor.authorT. Lautenschlager, Nicolaen_US
dc.contributor.authorS. Dhaliwal, Satvinderen_US
dc.contributor.authorJohnston, Amyen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.authorGandy, Samuelen_US
dc.contributor.authorK. Foster, Jonathanen_US
dc.contributor.authorN. Martins, Ralphen_US
dc.contributor.editorDr. George Perry, Mark A Smithen_US
dc.date.accessioned2017-05-03T15:24:43Z
dc.date.available2017-05-03T15:24:43Z
dc.date.issued2009en_US
dc.date.modified2010-08-19T07:05:00Z
dc.identifier.issn13872877en_US
dc.identifier.doi10.3233/JAD-2009-1020en_AU
dc.identifier.urihttp://hdl.handle.net/10072/30347
dc.description.abstractOlfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherIOS Pressen_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom135en_US
dc.relation.ispartofpageto142en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of Alzheimer's Diseaseen_US
dc.relation.ispartofvolume17en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode320705en_US
dc.subject.fieldofresearchcode321204en_US
dc.titleOlfactory Dysfunction is Associated with Subjective Memory Complaints in Community-Dwelling Elderly Individualsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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