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dc.contributor.authorLoughrey, Bradley T
dc.contributor.authorWilliams, Michael L
dc.contributor.authorHealy, Peter C
dc.contributor.authorInnocenti, Alessio
dc.contributor.authorVullo, Daniela
dc.contributor.authorSupuran, Claudiu T
dc.contributor.authorParsons, Peter G
dc.contributor.authorPoulsen, Sally-Ann
dc.contributor.editorLawrence Que
dc.date.accessioned2017-05-03T11:45:32Z
dc.date.available2017-05-03T11:45:32Z
dc.date.issued2009
dc.date.modified2010-07-13T07:14:30Z
dc.identifier.issn0949-8257
dc.identifier.doi10.1007/s00775-009-0506-8
dc.identifier.urihttp://hdl.handle.net/10072/30375
dc.description.abstractCationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide sandwich complexes have been synthesized and screened for enzymatic inhibition of the physiologically dominant carbonic anhydrase (CA) isozymes: human CA I and II, mitochondrial isozymes VA and VB, and the cancer-associated isozyme IX. The complexes demonstrated weaker binding to CAs compared with typical aromatic sulfonamides, inhibiting the enzyme at high nanomolar concentrations. An in vitro cytotoxic evaluation of the complexes was also undertaken against a range of tumorigenic cell lines and a healthy human cell line. Complexes inhibited the growth of cancerous cells at low micromolar concentrations while expressing lower levels of toxicity towards the normal human cell line. Factors influencing the synthesis, cytotoxicity, and enzyme affinity for this series of organometallic complexes are discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom935
dc.relation.ispartofpageto945
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Biological Inorganic Chemistry
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode3101
dc.titleNovel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorPoulsen, Sally-Ann


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