Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

Gunosewoyo, Hendra; Coster, Mark J; Bennett, Maxwell R; Kassiou, Michael

doi:10.1016/j.bmc.2009.05.083

Author(s)

Gunosewoyo, Hendra

Coster, Mark J

Bennett, Maxwell R

Kassiou, Michael

Griffith University Author(s)

Coster, Mark J.

Year published

2009

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Abstract

The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
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