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  • Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

    Author(s)
    Gunosewoyo, Hendra
    Coster, Mark J
    Bennett, Maxwell R
    Kassiou, Michael
    Griffith University Author(s)
    Coster, Mark J.
    Year published
    2009
    Metadata
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    Abstract
    The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
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    Journal Title
    Bioorganic & Medicinal Chemistry
    Volume
    17
    Issue
    14
    Publisher URI
    http://www.sciencedirect.com/science/journal/09680896
    DOI
    https://doi.org/10.1016/j.bmc.2009.05.083
    Subject
    Medicinal and biomolecular chemistry
    Biologically active molecules
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/30380
    Collection
    • Journal articles

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