Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening
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Gunosewoyo, Hendra
Coster, Mark J
Bennett, Maxwell R
Kassiou, Michael
Coster, Mark J
Bennett, Maxwell R
Kassiou, Michael
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2009
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Abstract
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
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Bioorganic & Medicinal Chemistry
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Subject
Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry
Pharmacology and pharmaceutical sciences
Biologically active molecules
Organic chemistry
Pharmacology and pharmaceutical sciences