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  • Pulmonary hypertension in systemic Lupus Erythematosus complicated by exposure to Dexfenfluramine

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    Author(s)
    Petcu, Eugen B
    Berman, Leonard
    Opris, Maria M
    Gheorghiu, Valentin
    Kessler, Stanton C
    Hayes, John
    Farber, Harrison W
    Griffith University Author(s)
    Petcu, Eugen B.
    Year published
    2009
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    Abstract
    Pulmonary arterial hypertension (PAH) is a well recognized, albeit uncommon, complication of systemic lupus erythematosus (SLE) and is characterized histologically by the presence of onionskin thickening of small arterioles. We described a 24 year-old female with SLE, complicated by pulmonary hypertension after a six-week exposure to dexfenfluramine, who died of acute myocardial infarction complicated with pneumococcal sepsis. Autopsy demonstrated pulmonary arteriolar thickening with severe sclerosis as well as the more advanced plexiform and angiomatoid lesions. Based on these findings, we hypothesize that in this case the ...
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    Pulmonary arterial hypertension (PAH) is a well recognized, albeit uncommon, complication of systemic lupus erythematosus (SLE) and is characterized histologically by the presence of onionskin thickening of small arterioles. We described a 24 year-old female with SLE, complicated by pulmonary hypertension after a six-week exposure to dexfenfluramine, who died of acute myocardial infarction complicated with pneumococcal sepsis. Autopsy demonstrated pulmonary arteriolar thickening with severe sclerosis as well as the more advanced plexiform and angiomatoid lesions. Based on these findings, we hypothesize that in this case the use of dexfenfluramine, albeit for a relatively short period, exerted a synergistic effect on the predisposition to PAH already inherent in this patient with SLE.
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    Journal Title
    Romanian Journal of Legal Medicine
    Volume
    17
    Issue
    2
    DOI
    https://doi.org/10.4323/rjlm.2009.83
    Copyright Statement
    © 2009 Bucura Mond Prod Com SRL. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Pathology (excl. oral pathology)
    Publication URI
    http://hdl.handle.net/10072/30434
    Collection
    • Journal articles

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