Total Synthesis of (+)-Angelmarin
Abstract
An efficient 8-step enantioselective total synthesis of (+)-angelmarin, starting from commercially available umbelliferone, has been achieved. Key reactions include olefin cross-metathesis and a Shi epoxidation-cyclization sequence.
Journal Title
Journal of Organic Chemistry
Volume
74
Issue
14
Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright 2009 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo900613u.
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Organic chemical synthesis