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dc.contributor.authorM. Mulvey, Jaminen_US
dc.contributor.authorRenshaw, Gillianen_US
dc.date.accessioned2017-04-24T08:59:12Z
dc.date.available2017-04-24T08:59:12Z
dc.date.issued2009en_US
dc.date.modified2010-10-29T06:35:18Z
dc.identifier.issn10956433en_US
dc.identifier.doi10.1016/j.cbpa.2008.10.017en_AU
dc.identifier.urihttp://hdl.handle.net/10072/30561
dc.description.abstractProlonged hypoxic exposure results in cell failure, glutamate excitotoxicity and apoptosis in the brain. The epaulette shark can withstand prolonged hypoxic exposure without brain injury, while maintaining normal function and activity at tropical temperatures. We examined whether the inhibitory neurotransmitter GABA was involved in hypoxia tolerance and neuroprotection during hypoxic preconditioning. Sharks were exposed to either cyclic hypoxic preconditioning or normoxic conditions. Whole brain GABA concentration was determined using high performance liquid chromatography; GABA distribution in neuronal structures was localised with immunohistochemistry and quantified. While the overall brain level of GABA was not significantly different, there was a significant heterogeneous change in GABA distribution. GABA immunoreactivity was elevated in key motor and sensory nuclei from preconditioned animals, including the nucleus motorius nervi vagi and the cerebellar crest (pb0.001), corresponding to areas of previously reported neuronal hypometabolism. Since the neuroprotection in all other hypoxia and anoxia tolerant species examined so far relies in part on significant elevations in GABA and the phylogenetically older epaulette shark does not, it is reasonable to assume that further research in this unique animal model may yield clues to new key modulators of neuroprotection. Understanding such mechanisms may facilitate the development of therapeutic interventions in the treatment of transient ischaemic attacks, strokes and traumatic brain injury.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom273en_US
dc.relation.ispartofpageto277en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalComparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiologyen_US
dc.relation.ispartofvolume152en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320307en_US
dc.titleGABA is not elevated during neuroprotective neuronal depression in the hypoxic epaulette sharken_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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