Show simple item record

dc.contributor.authorYelland, Michaelen_US
dc.contributor.authorJ. Poulos, Christopheren_US
dc.contributor.authorI. Pillans, Peteren_US
dc.contributor.authorM. Bashford, Guyen_US
dc.contributor.authorNikles, Catherine Janeen_US
dc.contributor.authorM. Sturtevant, Joannaen_US
dc.contributor.authorVine, Normaen_US
dc.contributor.authorB. Del Mar, Christopheren_US
dc.contributor.authorJ. Schluter, Philipen_US
dc.contributor.authorTan, Mengen_US
dc.contributor.authorChan, Jonathanen_US
dc.contributor.authorMackenzie, Fraseren_US
dc.contributor.authorBrown, Robynen_US
dc.date.accessioned2017-05-03T14:38:30Z
dc.date.available2017-05-03T14:38:30Z
dc.date.issued2009en_US
dc.date.modified2010-11-03T07:05:50Z
dc.identifier.issn15262375en_US
dc.identifier.doi10.1111/j.1526-4637.2009.00615.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/30570
dc.description.abstractObjective. The objective of this study was to compare the efficacy of gabapentin with placebo for neuropathic pain at the individual and population levels. Design. This study used an n-of-1 trial methodology with three double-blind, randomized, crossover comparisons of gabapentin with placebo. Setting. This study was carried out at specialist outpatient clinics at two Australian hospitals. Patients. The patients are adults with chronic neuropathic pain. Interventions. Following a dose-finding period, participants underwent three comparisons of 2-week periods on gabapentin (600-1,800 mg per day) and placebo. The dose-finding period was commenced by 112 patients, of whom 39 had no response so they did not enroll, leaving 73 trial participants. Of these, 48 completed and 7 partially completed their trials, and 18 withdrew. Outcome Measures. The five outcome measures were the visual analog scale (0-10) of pain, sleep interference and functional limitation; frequency of adverse events and medication preference. The aggregate response was determined by weighting the response to each measure equally. Results. Of the 55 participants who completed at least one cycle, the aggregate response to gabapentin was better than placebo in 16 (29%), of whom 15 continued gabapentin posttrial. No difference was shown in 38 (69%), and 1 (2%) showed a better response to placebo. Fifteen of these 39 continued gabapentin posttrial. Meta-analysis of the mean scores showed lower mean (standard deviation) scores for gabapentin by 0.8 (0.2) for pain, 0.6 (0.2) for sleep interference, and 0.6 (0.2) for functional limitation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent111741 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishingen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom754en_US
dc.relation.ispartofpageto761en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalPain Medicineen_US
dc.relation.ispartofvolume10en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)en_US
dc.subject.fieldofresearchcode170101en_US
dc.titleN-of-1 randomized trials to assess the efficacy of gabapentin for chronic neuropathic painen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medicineen_US
gro.rights.copyrightCopyright 2009 The American Academy of Pain Medicine. Published by Blackwell Publishing. This is the pre-peer reviewed version of the following article: N-of-1 randomized trials to assess the efficacy of gabapentin for chronic neuropathic pain, Pain Medicine Volume 10, Issue 4, 2009, 754-761, which has been published in final form at 10.1111/j.1526-4637.2009.00615.x.en_AU
gro.date.issued2009
gro.hasfulltextFull Text


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record