Cytotoxic effects of Bangladeshi medicinal plant extracts

View/ Open
Author(s)
Uddin, Shaikh J
Grice, I Darren
Tiralongo, Evelin
Year published
2011
Metadata
Show full item recordAbstract
To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, sixteen Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against ...
View more >To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, sixteen Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1-1.6 mg/mL). Seven methanolic extracts from Limnophila indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, Xylocarpus moluccensis and Aegiceras corniculatum showed low toxicity (IC50 >2.5 mg/mL) against mouse fibroblasts but selective cytotoxicity (IC50 0.2-2.3 mg/mL) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01-0.08 mg/mL) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anti-cancer treatments correlates with the cytotoxic results, whereas, for others so far unknown cytotoxic activities were identified.
View less >
View more >To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, sixteen Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1-1.6 mg/mL). Seven methanolic extracts from Limnophila indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, Xylocarpus moluccensis and Aegiceras corniculatum showed low toxicity (IC50 >2.5 mg/mL) against mouse fibroblasts but selective cytotoxicity (IC50 0.2-2.3 mg/mL) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01-0.08 mg/mL) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anti-cancer treatments correlates with the cytotoxic results, whereas, for others so far unknown cytotoxic activities were identified.
View less >
Journal Title
Evidence - Based Complementary and Alternative Medicine
Volume
2011
Copyright Statement
© 2009 Oxford University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Traditional, complementary and integrative medicine
Pharmacology and pharmaceutical sciences not elsewhere classified
Pharmacology and pharmaceutical sciences