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dc.contributor.authorUddin, Shaikhen_US
dc.contributor.authorGrice, Darrenen_US
dc.contributor.authorTiralongo, Evelinen_US
dc.contributor.editorProf. Dr Edwin L. Cooperen_US
dc.date.accessioned2017-04-24T11:53:48Z
dc.date.available2017-04-24T11:53:48Z
dc.date.issued2011en_US
dc.date.modified2013-05-29T00:23:58Z
dc.identifier.issn17414288en_US
dc.identifier.doi10.1093/ecam/nep111en_US
dc.identifier.urihttp://hdl.handle.net/10072/30665
dc.description.abstractTo investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, sixteen Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1-1.6 mg/mL). Seven methanolic extracts from Limnophila indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, Xylocarpus moluccensis and Aegiceras corniculatum showed low toxicity (IC50 >2.5 mg/mL) against mouse fibroblasts but selective cytotoxicity (IC50 0.2-2.3 mg/mL) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01-0.08 mg/mL) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anti-cancer treatments correlates with the cytotoxic results, whereas, for others so far unknown cytotoxic activities were identified.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent156281 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto7en_US
dc.relation.ispartofjournalEvidence - Based Complementary and Alternative Medicineen_US
dc.relation.ispartofvolume2011en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode111599en_US
dc.titleCytotoxic effects of Bangladeshi medicinal plant extractsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Pharmacyen_US
gro.rights.copyrightCopyright 2009 Oxford University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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