Cytotoxic agarofurans from the seeds of the Australian rainforest vine Celastrus subspicata
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An anti-inflammatory active extract from the seeds of the Australian rainforest vine Celastrus subspicata was identified from high throughput screening of a plant and marine invertebrate extract library using an assay which detects down regulation of expression of pro-inflammatory genes associated with the glucocorticoid receptor ligand complex. The anti-inflammatory properties of the extract were found to be associated with a group of fatty acids that were present in the extract in high yield. Two agarofurans were also isolated and shown to possessminimal anti-inflammatory activity and to be cytotoxic towards HeLa cancer cells.
© 2009 Phytochemical Society of Europe. Published by Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.