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  • Cytotoxic agarofurans from the seeds of the Australian rainforest vine Celastrus subspicata

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    Author(s)
    Carroll, Anthony R
    Davis, Rohan A
    Addepalli, Rama
    Fechner, Gregory A
    Guymer, Gordon P
    Forster, Paul I
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Davis, Rohan A.
    Addepalli, Rama
    Carroll, Anthony R.
    Fechner, Gregory A.
    Year published
    2009
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    Abstract
    An anti-inflammatory active extract from the seeds of the Australian rainforest vine Celastrus subspicata was identified from high throughput screening of a plant and marine invertebrate extract library using an assay which detects down regulation of expression of pro-inflammatory genes associated with the glucocorticoid receptor ligand complex. The anti-inflammatory properties of the extract were found to be associated with a group of fatty acids that were present in the extract in high yield. Two agarofurans were also isolated and shown to possessminimal anti-inflammatory activity and to be cytotoxic towards HeLa cancer cells.An anti-inflammatory active extract from the seeds of the Australian rainforest vine Celastrus subspicata was identified from high throughput screening of a plant and marine invertebrate extract library using an assay which detects down regulation of expression of pro-inflammatory genes associated with the glucocorticoid receptor ligand complex. The anti-inflammatory properties of the extract were found to be associated with a group of fatty acids that were present in the extract in high yield. Two agarofurans were also isolated and shown to possessminimal anti-inflammatory activity and to be cytotoxic towards HeLa cancer cells.
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    Journal Title
    Phytochemistry Letters
    Volume
    2
    Issue
    4
    DOI
    https://doi.org/10.1016/j.phytol.2009.05.002
    Copyright Statement
    © 2009 Phytochemical Society of Europe. Published by Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Medicinal and biomolecular chemistry
    Plant biology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/30697
    Collection
    • Journal articles

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