• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Lung-to-lung circulation times during exercise in heart failure

    Thumbnail
    View/Open
    61072_1.pdf (122.4Kb)
    Author(s)
    Morris, Norman R
    Snyder, Eric M
    Beck, Kenneth C
    Johnson, Bruce D
    Griffith University Author(s)
    Morris, Norman
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    Circulation time (the transit time for a bolus of blood through the circulatory system) is a potential index of cardiac dysfunction in chronic heart failure (HF). In healthy subjects, circulation time falls as cardiac output (Q) rises during exercise, however little is known about this index in HF. In this study we examined the relationship between lung-to-lung circulation time (LLCT) during exercise in ten HF (53 ᠱ4 year, resting ejection fraction = 23 ᠸ%) and control subjects (51 ᠱ8 year). We hypothesized that HF patients would have slower LLCT times during exercise when compared to control subjects. Each subject completed ...
    View more >
    Circulation time (the transit time for a bolus of blood through the circulatory system) is a potential index of cardiac dysfunction in chronic heart failure (HF). In healthy subjects, circulation time falls as cardiac output (Q) rises during exercise, however little is known about this index in HF. In this study we examined the relationship between lung-to-lung circulation time (LLCT) during exercise in ten HF (53 ᠱ4 year, resting ejection fraction = 23 ᠸ%) and control subjects (51 ᠱ8 year). We hypothesized that HF patients would have slower LLCT times during exercise when compared to control subjects. Each subject completed two identical incremental exercise tests during which LLCT was measured in one test and Q measured in the other. Q was measured using the open circuit C2H2 washin technique and circulation time measured using an inert gas technique. In HF patients and control subjects, LLCT decreased and Q increased from rest (HF:LLCT = 53.6 ᠸ.2 s, Q = 4.3 ᠱ.1 l min-1; control: LLCT = 55.3 ᠱ0.9 s, Q = 4.5 ᠰ.5 l min-1) to peak exercise (HF:LLCT = 20.6 ᠳ.9* s, Q = 8.8 ᠲ.5* l min-1; control:LLCT = 14.9 ᠲ.4 s, Q = 16.5 ᠱ.2 l min-1; *P < 0.05 vs control). LLCT was significantly (P < 0.05) slower for the HF group when compared to the control group during submaximal exercise and at peak exercise. However, at a fixed Q the HF subjects had a faster LLCT. We hypothesize that the faster LLCT at a fixed Q for HF patients, may be the result of a more intensive peripheral vasoconstriction of non-active beds and a better redistribution of blood flow.
    View less >
    Journal Title
    European Journal of Applied Physiology
    Volume
    106
    Issue
    4
    DOI
    https://doi.org/10.1007/s00421-009-1051-4
    Copyright Statement
    © 2009 Springer Berlin / Heidelberg. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The original publication is available at www.springerlink.com
    Subject
    Sports science and exercise
    Exercise physiology
    Publication URI
    http://hdl.handle.net/10072/30711
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander