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dc.contributor.authorMorris, Normanen_US
dc.contributor.authorM. Snyder, Ericen_US
dc.contributor.authorC. Beck, Kennethen_US
dc.contributor.authorD. Johnson, Bruceen_US
dc.date.accessioned2017-04-24T10:36:26Z
dc.date.available2017-04-24T10:36:26Z
dc.date.issued2009en_US
dc.date.modified2010-10-12T06:57:21Z
dc.identifier.issn14396319en_US
dc.identifier.doi10.1007/s00421-009-1051-4en_AU
dc.identifier.urihttp://hdl.handle.net/10072/30711
dc.description.abstractCirculation time (the transit time for a bolus of blood through the circulatory system) is a potential index of cardiac dysfunction in chronic heart failure (HF). In healthy subjects, circulation time falls as cardiac output (Q) rises during exercise, however little is known about this index in HF. In this study we examined the relationship between lung-to-lung circulation time (LLCT) during exercise in ten HF (53 ᠱ4 year, resting ejection fraction = 23 ᠸ%) and control subjects (51 ᠱ8 year). We hypothesized that HF patients would have slower LLCT times during exercise when compared to control subjects. Each subject completed two identical incremental exercise tests during which LLCT was measured in one test and Q measured in the other. Q was measured using the open circuit C2H2 washin technique and circulation time measured using an inert gas technique. In HF patients and control subjects, LLCT decreased and Q increased from rest (HF:LLCT = 53.6 ᠸ.2 s, Q = 4.3 ᠱ.1 l min-1; control: LLCT = 55.3 ᠱ0.9 s, Q = 4.5 ᠰ.5 l min-1) to peak exercise (HF:LLCT = 20.6 ᠳ.9* s, Q = 8.8 ᠲ.5* l min-1; control:LLCT = 14.9 ᠲ.4 s, Q = 16.5 ᠱ.2 l min-1; *P < 0.05 vs control). LLCT was significantly (P < 0.05) slower for the HF group when compared to the control group during submaximal exercise and at peak exercise. However, at a fixed Q the HF subjects had a faster LLCT. We hypothesize that the faster LLCT at a fixed Q for HF patients, may be the result of a more intensive peripheral vasoconstriction of non-active beds and a better redistribution of blood flow.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent125432 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom621en_US
dc.relation.ispartofpageto627en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalEuropean Journal of Applied Physiologyen_US
dc.relation.ispartofvolume106en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchExercise Physiologyen_US
dc.subject.fieldofresearchcode110602en_US
dc.titleLung-to-lung circulation times during exercise in heart failureen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2009 Springer Berlin / Heidelberg. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The original publication is available at www.springerlink.comen_AU
gro.date.issued2009
gro.hasfulltextFull Text


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