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dc.contributor.authorTaft, Ryan
dc.contributor.authorGlazov, Evgeny
dc.contributor.authorCloonan, Nicole
dc.contributor.authorSimons, Cas
dc.contributor.authorStephen, Stuart
dc.contributor.authorFaulkner, Geoffrey
dc.contributor.authorLassmann, Timo
dc.contributor.authorForrest, Alistair
dc.contributor.authorGrimmond, Sean
dc.contributor.authorSchroder, Kate
dc.contributor.authorIrvine, Katharine
dc.contributor.authorArakawa, Takahiro
dc.contributor.authorNakamura, Mari
dc.contributor.authorKubosaki, Atsutaka
dc.contributor.authorHayashida, Kengo
dc.contributor.authorKawazu, Chika
dc.contributor.authorMurata, Mitsuyoshi
dc.contributor.authorNishiyori, Hiromi
dc.contributor.authorFukuda, Shiro
dc.contributor.authorKawai, Jun
dc.contributor.authorDaub, Carsten
dc.contributor.authorHume, David
dc.contributor.authorSuzuki, Harukazu
dc.contributor.authorOrlando, Valerio
dc.contributor.authorCarninci, Piero
dc.contributor.authorHayashizaki, Yoshihide
dc.contributor.authorMattick, John
dc.date.accessioned2017-05-03T14:38:39Z
dc.date.available2017-05-03T14:38:39Z
dc.date.issued2009
dc.date.modified2010-07-08T01:08:35Z
dc.identifier.issn1061-4036
dc.identifier.doi10.1038/ng.312
dc.identifier.urihttp://hdl.handle.net/10072/30743
dc.description.abstractIt has been reported that relatively short RNAs of heterogeneous sizes are derived from sequences near the promoters of eukaryotic genes. As part of the FANTOM4 project, we have identified tiny RNAs with a modal length of 18 nt that map within -60 to +120 nt of transcription start sites (TSSs) in human, chicken and Drosophila. These transcription initiation RNAs (tiRNAs) are derived from sequences on the same strand as the TSS and are preferentially associated with G+C-rich promoters. The 5' ends of tiRNAs show peak density 10-30 nt downstream of TSSs, indicating that they are processed. tiRNAs are generally, although not exclusively, associated with highly expressed transcripts and sites of RNA polymerase II binding. We suggest that tiRNAs may be a general feature of transcription in metazoa and possibly all eukaryotes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom572
dc.relation.ispartofpageto578
dc.relation.ispartofissue5
dc.relation.ispartofjournalNature Genetics
dc.relation.ispartofvolume41
dc.rights.retentionY
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060499
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleTiny RNAs associated with transcription start sites in animals
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorForrest, Alistair RR.


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