Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?

Smeesters, Pierre R; McMillan, David J; Sriprakash, Kadaba S; Georgousakis, Melina M

doi:10.1586/erv.09.133

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Author(s)

Smeesters, Pierre R

McMillan, David J

Sriprakash, Kadaba S

Georgousakis, Melina M

Griffith University Author(s)

McMillan, David J.

Sriprakash, Kadaba S.

Year published

2009

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Abstract

Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.
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Journal Title

Expert Review of Vaccines

Volume

Issue

DOI

https://doi.org/10.1586/erv.09.133

Copyright Statement

© 2009 Expert Reviews Ltd.. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

Subject

Medical Biochemistry and Metabolomics not elsewhere classified

Clinical Sciences

Public Health and Health Services

Publication URI

http://hdl.handle.net/10072/30749

Collection

Journal articles