Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?

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Author(s)
Smeesters, Pierre R
McMillan, David J
Sriprakash, Kadaba S
Georgousakis, Melina M
Year published
2009
Metadata
Show full item recordAbstract
Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.
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Journal Title
Expert Review of Vaccines
Volume
8
Issue
12
Copyright Statement
© 2009 Expert Reviews Ltd.. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Medical biochemistry and metabolomics not elsewhere classified
Clinical sciences