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dc.contributor.authorHolmes, Roger S
dc.date.accessioned2017-05-03T15:51:49Z
dc.date.available2017-05-03T15:51:49Z
dc.date.issued2010
dc.date.modified2010-10-19T07:00:22Z
dc.identifier.issn0006-2928
dc.identifier.doi10.1007/s10528-009-9318-3
dc.identifier.urihttp://hdl.handle.net/10072/30852
dc.description.abstractMammalian ALDH3 isozymes participate in peroxidic and fatty aldehyde metabolism, and in anterior eye tissue UV-filtration. BLAT analyses were undertaken of the opossum genome using rat ALDH3A1, ALDH3A2, ALDH3B1, and ALDH3B2 amino acid sequences. Two predicted opossum ALDH3A1-like genes and an ALDH3A2-like gene were observed on chromosome 2, as well as an ALDH3B-like gene, which showed similar intron-exon boundaries w ith other mammalian ALDH3-like genes. Opossum ALDH3 subunit sequences and structures were highly conserved, including residues previously shown to be involved in catalysis and coenzyme binding for rat ALDH3A1. Eleven glycine residues were conserved for all of the opossum ALDH3-like sequences examined, including two glycine residues previously located within the stem of the rat ALDH3A1 active site funnel. Phylogeny studies of human, rat, opossum, and chicken ALDH3-like sequences indicated that the common ancestor for ALDH3A- and ALDH3B-like genes predates the appearance of birds during vertebrate evolution.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent703371 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherKluwer Academic
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom287
dc.relation.ispartofpageto303
dc.relation.ispartofissue3-4
dc.relation.ispartofjournalBiochemical Genetics
dc.relation.ispartofvolume48
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode310599
dc.titleBiochemical Genetics of Opossum Aldehyde Dehydrogenase 3: Evidence for Three ALDH3A-Like Genes and an ALDH3B-Like Gene
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2010 Springer Netherlands. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The original publication is available at www.springerlink.com
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorHolmes, Roger S.


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