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dc.contributor.authorPeart, Jason N
dc.contributor.authorHeadrick, John P
dc.date.accessioned2017-05-03T11:16:45Z
dc.date.available2017-05-03T11:16:45Z
dc.date.issued2009
dc.identifier.issn0363-6135
dc.identifier.doi10.1152/ajpheart.00162.2009
dc.identifier.urihttp://hdl.handle.net/10072/31027
dc.description.abstractAdjunctive cardioprotective strategies for ameliorating the reversible and irreversible injuries with ischemia-reperfusion (I/R) are highly desirable. However, after decades of research, the promise of clinical cardioprotection from I/R injury remains poorly realized. This may arise from the challenges of trialing and effectively translating experimental findings from laboratory models to patients. One can additionally consider whether features of the more heavily focused upon candidates could limit or preclude therapeutic utility and thus whether we might shift attention to alternate strategies. The phenomena of preconditioning and postconditioning have proven fertile in identification of experimental means of cardioprotection and are the most intensely interrogated responses in the field. However, there is evidence these processes, which share common molecular signaling elements and end effectors, may be poor choices for clinical exploitation. This includes evidence of age dependence, limiting efficacy in target aged or senescent hearts; refractoriness to conditioning stimuli in diseased myocardium; interference from a variety of relevant pharmaceuticals; inadvertent induction of these responses by prior ischemia or commonly used drugs, precluding further benefit; and sex dependence of protective signaling. This review focuses on these features, raising questions about current research strategies, and the suitability of these widely studied phenomena as rational candidates for clinical translation.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefromH1705
dc.relation.ispartofpagetoH1720
dc.relation.ispartofissue6
dc.relation.ispartofjournalAmerican Journal of Physiology: Heart and Circulatory Physiology
dc.relation.ispartofvolume296
dc.rights.retentionY
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode3201
dc.titleClinical cardioprotection and the value of conditioning responses
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2015-04-22T05:40:42Z
gro.hasfulltextNo Full Text
gro.griffith.authorHeadrick, John P.
gro.griffith.authorPeart, Jason N.


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