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  • Synthesis, structure and selective cytotoxicity of organometallic Cp*Ru^[II] O-Alkyl-N-phenylcarbamate sandwich complexes

    Author(s)
    Loughrey, Bradley T
    Williams, Michael L
    Carruthers, Thomas J
    Parsons, Peter G
    Healy, Peter C
    Griffith University Author(s)
    Healy, Peter C.
    Williams, Michael L.
    Loughrey, Bradley T.
    Parsons, Peter G.
    Carruthers, Thomas J.
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Tetraphenylborate salts of the ?6-arene Cp*RuII O-alkyl-N-phenyl carbamate organometallic sandwich complexes, [Cp*Ru(PhNHCO2R)]BPh4 for R = Me (1), Et (2), and n-Pr (3), have been prepared by a facile one-pot reaction between ruthenium trichloride, pentamethylcyclopentadiene, and phenylisocyanate in refluxing alcohol solutions, and have been characterized by Fourier-transform IR and NMR spectroscopy, electrospray mass spectrometry, and single-crystal X-ray structure determinations. In vitro cytotoxicity studies show the complexes to be potent growth inhibitors for a range of tumour cell lines, while expressing significantly ...
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    Tetraphenylborate salts of the ?6-arene Cp*RuII O-alkyl-N-phenyl carbamate organometallic sandwich complexes, [Cp*Ru(PhNHCO2R)]BPh4 for R = Me (1), Et (2), and n-Pr (3), have been prepared by a facile one-pot reaction between ruthenium trichloride, pentamethylcyclopentadiene, and phenylisocyanate in refluxing alcohol solutions, and have been characterized by Fourier-transform IR and NMR spectroscopy, electrospray mass spectrometry, and single-crystal X-ray structure determinations. In vitro cytotoxicity studies show the complexes to be potent growth inhibitors for a range of tumour cell lines, while expressing significantly lower levels of toxicity towards a normal human fibroblast cell line.
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    Journal Title
    Australian Journal of Chemistry
    Volume
    63
    Issue
    2
    DOI
    https://doi.org/10.1071/CH09420
    Subject
    Chemical sciences
    Bioinorganic chemistry
    Publication URI
    http://hdl.handle.net/10072/31114
    Collection
    • Journal articles

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