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  • Sialic acid dependence in rotavirus host cell invasion

    Author(s)
    Haselhorst, Thomas
    Fleming, Fiona E
    Dyason, Jeffrey C
    Hartnell, Regan D
    Yu, Xing
    Holloway, Gavan
    Santegoets, Kim
    Kiefel, Milton J
    Blanchard, Helen
    Coulson, Barbara S
    von Itzstein, Mark
    Griffith University Author(s)
    von Itzstein, Mark
    Kiefel, Milton
    Dyason, Jeffrey C.
    Haselhorst, Thomas E.
    Coulson, Barbara
    Blanchard, Helen
    Hartnell, Regan D.
    Yu, Xing
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.
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    Journal Title
    Nature Chemical Biology
    Volume
    5
    Issue
    2
    DOI
    https://doi.org/10.1038/nchembio.134
    Subject
    Characterisation of Biological Macromolecules
    Medicinal and Biomolecular Chemistry
    Biochemistry and Cell Biology
    Publication URI
    http://hdl.handle.net/10072/31265
    Collection
    • Journal articles

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