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dc.contributor.authorHaselhorst, Thomas
dc.contributor.authorFleming, Fiona E
dc.contributor.authorDyason, Jeffrey C
dc.contributor.authorHartnell, Regan D
dc.contributor.authorYu, Xing
dc.contributor.authorHolloway, Gavan
dc.contributor.authorSantegoets, Kim
dc.contributor.authorKiefel, Milton J
dc.contributor.authorBlanchard, Helen
dc.contributor.authorCoulson, Barbara S
dc.contributor.authorvon Itzstein, Mark
dc.date.accessioned2018-01-23T01:00:23Z
dc.date.available2018-01-23T01:00:23Z
dc.date.issued2009
dc.date.modified2010-07-07T09:44:20Z
dc.identifier.issn1552-4450
dc.identifier.doi10.1038/nchembio.134
dc.identifier.urihttp://hdl.handle.net/10072/31265
dc.description.abstractWe used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom91
dc.relation.ispartofpageto93
dc.relation.ispartofissue2
dc.relation.ispartofjournalNature Chemical Biology
dc.relation.ispartofvolume5
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchCharacterisation of biological macromolecules
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340403
dc.subject.fieldofresearchcode3101
dc.titleSialic acid dependence in rotavirus host cell invasion
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorKiefel, Milton
gro.griffith.authorHaselhorst, Thomas E.


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