dc.contributor.author | Haselhorst, Thomas | |
dc.contributor.author | Fleming, Fiona E | |
dc.contributor.author | Dyason, Jeffrey C | |
dc.contributor.author | Hartnell, Regan D | |
dc.contributor.author | Yu, Xing | |
dc.contributor.author | Holloway, Gavan | |
dc.contributor.author | Santegoets, Kim | |
dc.contributor.author | Kiefel, Milton J | |
dc.contributor.author | Blanchard, Helen | |
dc.contributor.author | Coulson, Barbara S | |
dc.contributor.author | von Itzstein, Mark | |
dc.date.accessioned | 2018-01-23T01:00:23Z | |
dc.date.available | 2018-01-23T01:00:23Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2010-07-07T09:44:20Z | |
dc.identifier.issn | 1552-4450 | |
dc.identifier.doi | 10.1038/nchembio.134 | |
dc.identifier.uri | http://hdl.handle.net/10072/31265 | |
dc.description.abstract | We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.publisher.place | USA | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 91 | |
dc.relation.ispartofpageto | 93 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Nature Chemical Biology | |
dc.relation.ispartofvolume | 5 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Characterisation of biological macromolecules | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340403 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.title | Sialic acid dependence in rotavirus host cell invasion | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2009 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | von Itzstein, Mark | |
gro.griffith.author | Kiefel, Milton | |
gro.griffith.author | Haselhorst, Thomas E. | |