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dc.contributor.authorHaselhorst, Thomasen_US
dc.contributor.authorFleming, Fionaen_US
dc.contributor.authorDyason, Jeffreyen_US
dc.contributor.authorHartnell, Reganen_US
dc.contributor.authorYu, Xingen_US
dc.contributor.authorHolloway, Gavanen_US
dc.contributor.authorSantegoets, Kimen_US
dc.contributor.authorKiefel, Miltonen_US
dc.contributor.authorBlanchard, Helenen_US
dc.contributor.authorCoulson, Barbaraen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.date.accessioned2017-05-03T11:05:51Z
dc.date.available2017-05-03T11:05:51Z
dc.date.issued2009en_US
dc.date.modified2010-07-07T09:44:20Z
dc.identifier.issn1552-4450en_US
dc.identifier.doi10.1038/nchembio.134en_AU
dc.identifier.urihttp://hdl.handle.net/10072/31265
dc.description.abstractWe used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUSAen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom91en_US
dc.relation.ispartofpageto93en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalNature Chemical Biologyen_US
dc.relation.ispartofvolume5en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchCharacterisation of Biological Macromoleculesen_US
dc.subject.fieldofresearchcode030403en_US
dc.titleSialic acid dependence in rotavirus host cell invasionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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