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dc.contributor.authorBowen, Richard J
dc.contributor.authorNavarro, Maribel
dc.contributor.authorShearwood, Anne-Marie J
dc.contributor.authorHealy, Peter C
dc.contributor.authorSkelton, Brian W
dc.contributor.authorFilipovska, Aleksandra
dc.contributor.authorBerners-Price, Susan J
dc.date.accessioned2018-02-13T03:28:36Z
dc.date.available2018-02-13T03:28:36Z
dc.date.issued2009
dc.date.modified2010-07-07T09:44:22Z
dc.identifier.issn1477-9226
dc.identifier.doi10.1039/b912281h
dc.identifier.urihttp://hdl.handle.net/10072/31266
dc.description.abstractThe 1 : 2 adducts of copper(I) halides with 1,2-bis(2-pyridylphosphino)ethane (d2pype) have been synthesized and solution properties characterized by variable temperature 1H, 31P and 65Cu NMR spectroscopy. Single-crystal structure determinations for the chloride, bromide and iodide complexes show these to crystallize from acetonitrile in the triclinic space group Pﱠas isostructural centrosymmetric dimers [(d2pype)Cu(m-d2pype)2Cu(d2pype)]X2砨solvent) with a ~ 12.6, b ~ 12.7, c ~15.3Aࠬ a ~ 84, b ~ 67, g ~ 84?. In contrast to the analogous AuCl:2(d2pype) and AgNO3:2(d2pype) adducts, in solution these CuX:2(d2pype) adducts (where X = Cl, Br and I) exist almost exclusively as bis-chelated monomeric [Cu(d2pype)2]X; evidence for an equilibrium between monomeric and dimeric forms is detected only for the CuCl adduct in methanol. Cytotoxicity studies in two human breast cancer lines and two matched liver progenitor cell lines indicate that [Cu(d2pype)2]Cl is non selectively toxic to both non-tumourigenic and tumourigenic cells. However, the analogous Au(I) compound [Au(d2pype)2]Cl, is toxic to highly tumourigenic cells and more selective in its toxicity to tumourigenic cells compared to non-tumourigenic cells. The significance of these results to the further development of selective, mitochondria-targeted, Au(I) antitumour complexes is discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom10861
dc.relation.ispartofpageto10870
dc.relation.ispartofissueN/A
dc.relation.ispartofjournalDalton Transactions
dc.relation.ispartofvolume48
dc.relation.urihttp://purl.org/au-research/grants/ARC/DP0986318
dc.relation.grantIDDP0986318
dc.relation.fundersARC
dc.rights.retentionY
dc.subject.fieldofresearchBioinorganic Chemistry
dc.subject.fieldofresearchInorganic Chemistry
dc.subject.fieldofresearchTheoretical and Computational Chemistry
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchcode030201
dc.subject.fieldofresearchcode0302
dc.subject.fieldofresearchcode0307
dc.subject.fieldofresearchcode0399
dc.title1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorBowen, Richard
gro.griffith.authorBerners-Price, Sue J.


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