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dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorFilipovska, Aleksandraen_US
dc.contributor.authorHealy, Peteren_US
dc.contributor.authorJ. Shearwood, Anne-Marieen_US
dc.contributor.authorNavarro, Maribelen_US
dc.contributor.authorW. Skelton, Brianen_US
dc.date.accessioned2017-04-04T22:07:18Z
dc.date.available2017-04-04T22:07:18Z
dc.date.issued2009en_US
dc.date.modified2010-07-07T09:44:22Z
dc.identifier.issn1477-9226en_US
dc.identifier.doi10.1039/b912281hen_AU
dc.identifier.urihttp://hdl.handle.net/10072/31266
dc.description.abstractThe 1 : 2 adducts of copper(I) halides with 1,2-bis(2-pyridylphosphino)ethane (d2pype) have been synthesized and solution properties characterized by variable temperature 1H, 31P and 65Cu NMR spectroscopy. Single-crystal structure determinations for the chloride, bromide and iodide complexes show these to crystallize from acetonitrile in the triclinic space group Pﱠas isostructural centrosymmetric dimers [(d2pype)Cu(m-d2pype)2Cu(d2pype)]X2砨solvent) with a ~ 12.6, b ~ 12.7, c ~15.3Aࠬ a ~ 84, b ~ 67, g ~ 84?. In contrast to the analogous AuCl:2(d2pype) and AgNO3:2(d2pype) adducts, in solution these CuX:2(d2pype) adducts (where X = Cl, Br and I) exist almost exclusively as bis-chelated monomeric [Cu(d2pype)2]X; evidence for an equilibrium between monomeric and dimeric forms is detected only for the CuCl adduct in methanol. Cytotoxicity studies in two human breast cancer lines and two matched liver progenitor cell lines indicate that [Cu(d2pype)2]Cl is non selectively toxic to both non-tumourigenic and tumourigenic cells. However, the analogous Au(I) compound [Au(d2pype)2]Cl, is toxic to highly tumourigenic cells and more selective in its toxicity to tumourigenic cells compared to non-tumourigenic cells. The significance of these results to the further development of selective, mitochondria-targeted, Au(I) antitumour complexes is discussed.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherRoyal Society of Chemistryen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom10861en_US
dc.relation.ispartofpageto10870en_US
dc.relation.ispartofissueN/Aen_AU
dc.relation.ispartofjournalDalton Transactionsen_US
dc.relation.ispartofvolume48en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBioinorganic Chemistryen_US
dc.subject.fieldofresearchcode030201en_US
dc.title1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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