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dc.contributor.authorMackay-Sim, A
dc.contributor.authorChuah, MI
dc.date.accessioned2017-05-03T13:46:10Z
dc.date.available2017-05-03T13:46:10Z
dc.date.issued2000
dc.date.modified2009-09-22T05:50:48Z
dc.identifier.issn0301-0082
dc.identifier.doi10.1016/S0301-0082(00)00009-5
dc.identifier.urihttp://hdl.handle.net/10072/3154
dc.description.abstractThe number of identified growth factors continues to increase rapidly with many being implicated in the development of the nervous system, although for most of them the autocrine and paracrine pathways of cellular regulation still remain to be elucidated. The primary olfactory pathway, consisting of the olfactory epithelium and olfactory bulb, is presented here as a very useful model for the analysis of growth factor function. Review of the available literature suggests that a large proportion of neuroactive growth factors and their receptors are present in the olfactory epithelium or olfactory bulb. Furthermore, the primary olfactory pathway is one of the most plastic in the nervous system with neurogenesis continuing to contribute new sensory neurones in the olfactory epithelium and new interneurones in the olfactory bulb throughout adult life. The rich diversity of growth factors and their receptors in the olfactory system indicates that it will be useful in elucidating how these molecules regulate the formation of the nervous system. The olfactory epithelium in particular is proving useful as a model for the actions of growth factors in directing the neuronal lineage from stem cell to mature neurone.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUK
dc.publisher.urihttp://www.sciencedirect.com/science/journal/03010082
dc.relation.ispartofpagefrom527
dc.relation.ispartofpageto553
dc.relation.ispartofjournalProgress in Neurobiology
dc.relation.ispartofvolume62
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleNeurotrophic growth factors in the primary olfactory pathway.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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