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  • Benzylpiperazine: a drug of abuse?

    Author(s)
    Johnstone, Alice C.
    Lea, Rod A.
    Brennan, Katie A.
    Schenk, Susan
    Kennedy, Martin A.
    Fitzmaurice, Paul S.
    Griffith University Author(s)
    Lea, Rodney A.
    Year published
    2007
    Metadata
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    Abstract
    N-benzylpiperazine (BZP) is the active ingredient in recreational 'party' or 'p.e.p.' pills, which are used to provide a stimulant, euphoric effect akin to that of methylenedioxymethamphetamine (MDMA, 'ecstasy'). BZP predominantly affects dopamine neurotransmission in a similar fashion to known 'drugs of abuse', such as methamphetamine and cocaine, which strongly suggests BZP has abuse liability. BZP is illegal in many countries including the United States of America and Australia, yet it remains legal in the United Kingdom, Canada and New Zealand. There has been little research, to date, on the neurological consequences of ...
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    N-benzylpiperazine (BZP) is the active ingredient in recreational 'party' or 'p.e.p.' pills, which are used to provide a stimulant, euphoric effect akin to that of methylenedioxymethamphetamine (MDMA, 'ecstasy'). BZP predominantly affects dopamine neurotransmission in a similar fashion to known 'drugs of abuse', such as methamphetamine and cocaine, which strongly suggests BZP has abuse liability. BZP is illegal in many countries including the United States of America and Australia, yet it remains legal in the United Kingdom, Canada and New Zealand. There has been little research, to date, on the neurological consequences of high dose or chronic exposure of BZP. Here we provide a comprehensive review of the information currently available on BZP and suggest a need for further research into the mechanisms of action, long-term effects and potentially addictive properties of BZP.
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    Journal Title
    Journal of Psychopharmacology
    Volume
    21
    Issue
    8
    DOI
    https://doi.org/10.1177/0269881107077260
    Subject
    Pharmacology and Pharmaceutical Sciences not elsewhere classified
    Medical and Health Sciences
    Psychology and Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/32045
    Collection
    • Journal articles

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