Show simple item record

dc.contributor.authorKeech, AC
dc.contributor.authorScott, R
dc.contributor.authorBest, J
dc.contributor.authorForder, P
dc.contributor.authorTaskinen, MR
dc.contributor.authorSimes, J
dc.contributor.authorBarter, P
dc.contributor.authorColman, P
dc.contributor.authord'Emden, M
dc.contributor.authorDavis, T
dc.contributor.authorDrury, P
dc.contributor.authorEhnholm, C
dc.contributor.authorGlasziou, P
dc.contributor.authorHunt, D
dc.contributor.authorKesaniemi, YA
dc.contributor.authorLaakso, M
dc.contributor.authorSimes, RJ
dc.contributor.authorSullivan, D
dc.contributor.authorWhiting, M
dc.contributor.authorAnsquer, JC
dc.contributor.authorFraitag, B
dc.contributor.authorAnderson, N
dc.contributor.authorHankey, G
dc.contributor.authorLehto, S
dc.contributor.authorMann, S
dc.contributor.authorRomo, M
dc.contributor.authorLi, LP
dc.contributor.authorHennekens, C
dc.contributor.authorMacMahon, S
dc.contributor.authorPocock, S
dc.contributor.authorTonkin, A
dc.contributor.authorWilhelmsen, L
dc.contributor.authorAkauola, H
dc.contributor.authorAlford, F
dc.contributor.authorBeinart, I
dc.contributor.authorBohra, S
dc.contributor.authorBoyages, S
dc.contributor.authorConnor, H
dc.contributor.authorDarnell, D
dc.contributor.authorDavoren, P
dc.contributor.authorLepre, F
dc.contributor.authorDe Looze, F
dc.contributor.authorDuffield, A
dc.contributor.authorFassett, R
dc.contributor.authorFlack, J
dc.contributor.authorFulcher, G
dc.contributor.authorGrant, S
dc.contributor.authorHamwood, S
dc.contributor.authorHarmelin, D
dc.contributor.authorJackson, R
dc.contributor.authorJeffries, W
dc.contributor.authorKamp, M
dc.contributor.authorKritharides, L
dc.contributor.authorMahar, L
dc.contributor.authorMcCann, V
dc.contributor.authorMcIntyre, D
dc.contributor.authorMoses, R
dc.contributor.authorNewnham, H
dc.contributor.authorNicholson, G
dc.contributor.authorO'Brien, R
dc.contributor.authorPark, K
dc.contributor.authorPetrovsky, N
dc.contributor.authorPhillips, P
dc.contributor.authorPinn, G
dc.contributor.authorSimmons, D
dc.contributor.authorStanton, K
dc.contributor.authorStuckey, B
dc.contributor.authorSullivan, DR
dc.contributor.authorSuranyi, M
dc.contributor.authorSuthers, M
dc.contributor.authorTan, Y
dc.contributor.authorTempler, M
dc.contributor.authorTopliss, D
dc.contributor.authorWaites, JH
dc.contributor.authorWatts, G
dc.contributor.authorWelborn, T
dc.contributor.authorWyndham, R
dc.contributor.authorHaapamaki, H
dc.contributor.authorKesaniemi, A
dc.contributor.authorLaakso, M
dc.contributor.authorLahtela, J
dc.contributor.authorLevanen, H
dc.contributor.authorSaltevo, J
dc.contributor.authorSodervik, H
dc.contributor.authorTaskinen, M
dc.contributor.authorVanhala, M
dc.contributor.authorBaker, J
dc.contributor.authorBurton, A
dc.contributor.authorDixon, P
dc.contributor.authorDoran, J
dc.contributor.authorDrury, P
dc.contributor.authorDunn, P
dc.contributor.authorGraham, N
dc.contributor.authorHamer, A
dc.contributor.authorHedley, J
dc.contributor.authorLloyd, J
dc.contributor.authorManning, P
dc.contributor.authorMcPherson, I
dc.contributor.authorMorris, S
dc.date.accessioned2017-09-04T03:16:32Z
dc.date.available2017-09-04T03:16:32Z
dc.date.issued2005
dc.identifier.issn1475-2840
dc.identifier.doi10.1186/1475-2840-4-13
dc.identifier.urihttp://hdl.handle.net/10072/32084
dc.description.abstractObjective: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study is examining the effects of long-term fibrate therapy on coronary heart disease (CHD) event rates in patients with diabetes mellitus. This article describes the trial's run-in phase and patients' baseline characteristics. Research design and methods: FIELD is a double-blind, placebo-controlled trial in 63 centres in 3 countries evaluating the effects of fenofibrate versus placebo on CHD morbidity and mortality in 9795 patients with type 2 diabetes mellitus. Patients were to have no indication for lipid-lowering therapy on randomization, but could start these or other drugs at any time after randomization. Follow-up in the study was to be for a median duration of not less than 5 years and until 500 major coronary events (fatal coronary heart disease plus nonfatal myocardial infarction) had occurred. Results: About 2100 patients (22%) had some manifestation of cardiovascular disease (CVD) at baseline and thus high risk status. Less than 25% of patients without CVD had a (UKPDS determined) calculated 5-year CHD risk of <5%, but nearly all had a 5-year stroke risk of <10%. Despite this, half of the cohort were obese (BMI > 30), most were men, two-thirds were aged over 60 years, and substantial proportions had NCEP ATP III features of the metabolic syndrome independent of their diabetes, including low HDL (60%), high blood pressure measurement or treatment for hypertension (84%), high waist measurement (68%), and raised triglycerides (52%). After a 6-week run-in period before randomisation with all participants receiving 200 mg comicronized fenofibrate, there were declines in total and LDL cholesterol (10%) and triglycerides (26%) and an increase in HDL cholesterol (6.5%). Conclusion: The study will show the effect of PPAR-alpha agonist action on CHD and other vascular outcomes in patients with type 2 diabetes including substantial numbers with low to moderate CVD risk but with the various components of the metabolic syndrome. The main results of the study will be reported in late 2005.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom13-1
dc.relation.ispartofpageto13-9
dc.relation.ispartofissue1
dc.relation.ispartofjournalCardiovascular Diabetology
dc.relation.ispartofvolume4
dc.rights.retentionY
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchcode1102
dc.titleFenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
dc.description.versionVersion of Record (VoR)
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 13.
gro.rights.copyright© 2005 Keech and The FIELD Study Investigators; licensee BioMed Central Ltd.. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2014-10-10T01:55:56Z
gro.hasfulltextFull Text
gro.griffith.authorHamilton-Craig, Ian
gro.griffith.authorDavoren, Peter M.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record