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dc.contributor.authorJ. Elser, James
dc.contributor.authorF. Fagan, William
dc.contributor.authorSubramanian, Sankar
dc.contributor.authorKumar, Sudhir
dc.date.accessioned2017-05-03T13:47:21Z
dc.date.available2017-05-03T13:47:21Z
dc.date.issued2006
dc.identifier.issn07374038
dc.identifier.doi10.1093/molbev/msl068
dc.identifier.urihttp://hdl.handle.net/10072/32101
dc.description.abstractAlthough substantial and ecologically significant differences in elemental composition are well documented for whole organisms, little is known about whether such differences extend to lower levels of biological organization, such as the elemental composition of major molecules. In a proteome-scale investigation of 9 plant genomes and 9 animal genomes, we find that the nitrogen (N) content of plant proteins is lower than that in animal proteins. Furthermore, protein N content declines with the intensity of gene expression for plants, whereas the N content of animal proteins shows no consistent pattern with expression. Additional analyses indicate that the differences in N content between plant and animal proteomes and in plant proteins as a function of gene expression cannot be attributed to protein size, GC content, gene function, or amino acid properties. These patterns suggest that ecophysiological selection has operated to conserve N in plants via decreased reliance on N-rich amino acids. This inference was supported by an analysis of conserved and variable sites indicating that the N content of plant amino acids coded by variable sites is similar to that of the sites conserved between plant and animal genomes and shows no association with expression level. In contrast, in animals, the N content of amino acids coded by variable sites is significantly higher than that for conserved sites, suggesting relaxation of selective constraints for N usage in the animal lineage. This constitutes the first evidence for an influence of environmental resource availability on proteomes of multicellular organisms.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1946
dc.relation.ispartofpageto1951
dc.relation.ispartofissue10
dc.relation.ispartofjournalMolecular Biology and Evolution
dc.relation.ispartofvolume23
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchEvolutionary Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0603
dc.subject.fieldofresearchcode0604
dc.titleSignatures of Ecological Resource Availability in the Animal and Plant Proteomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-13T03:20:51Z
gro.hasfulltextNo Full Text
gro.griffith.authorSankarasubramanian, Sankar


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